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文献和实验In Vitro Characterization of Intestinal Transporter, Breast Cancer Resistance Protein (BCRP)
The organ distribution and substrate specificity of breast cancer resistance protein (BCRP), the product of the human ABCG2 gene, overlaps considerably with that of P-glycoprotein. Both are up-regulated in some cancers, leading to drug
Osteoblast-like Cells Objective: To characterize the effects of E2 on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs) in human osteosarcoma cell line MG-63 and normal human osteoblast(hOB
Oral Thrombin Inhibitor Ximelagatran
Preclinical and initial clinical experiences with the direct oral thrombin inhibitor ximelagatran demonstrated both a short and long-term potential utility for this agent in the prevention and treatment of various thromboembolic disorders
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