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AJE 润色服务限时 8 折起,权威机构信任 15+ 年Cytoscape 教程来了!快速实现顶刊同款通路网络图五大应用案例:Mustang Q 膜层析应用全解析1 个小工具,一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 保质期:
12 months
- 英文名:
Research Grade Anti-Human CD366/HAVCR2/TIM-3 (LY3321367)
- 供应商:
武汉益普生物科技有限公司
- 规格:
100μg/1mg
| 规格: | 100μg | 产品价格: | ¥2288.0 |
|---|---|---|---|
| 规格: | 1mg | 产品价格: | ¥6788.0 |
| 产品名称 | Research Grade Anti-Human CD366/HAVCR2/TIM-3 (LY3321367) |
| 货号 | HV029106 |
| 描述 | Anti-Human CD366/HAVCR2/TIM-3 (LY3321367) ( HV029106 ) is a research-grade recombinant antibody targeting CD366 . Produced in mammalian cells with native-like glycosylation. Highlights Research Grade — For PK/PD studies, assay development, and ADA research. Native Glycosylation — Mammalian expression ensures native-like patterns. |
| 反应种属 | Human |
| 应用实验 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主/表达体系 | Human |
| 靶点 | T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3 |
| 基因号 | Q8TDQ0 |
| 状态 | Liquid |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 储存温度 | -20℃ |
| 别名 | LY3321367 |

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文献和实验-bin/carddisp.pl?gene=HAVCR2&keywords=CD366 TIM3作为重要的细胞免疫负调控因子,高表达于辅助型T细胞(Thl细胞)和细胞毒性T细胞中(Tcl细胞),并产生抑制信号从而导致Thl细胞和Tcl细胞的凋亡。其配体为半乳凝素9(Gal-9),这是一种被广泛表达的可溶性分子[7],与TIM3分子的免疫球蛋白可变区上的寡聚糖结合,从而对Thl驱动的免疫反应产生负调控作用。当TIM3与其配体半乳凝素9(Gal-9)结合后,促进Thl细胞凋亡[8] 。也就是说
Determining Ligand Specificity of Ly49 Receptors
Ly49 receptors in rodents, like KIR in humans, play an integral role in the regulation of NK cell activity. Some inhibitory Ly49 are known to interact with specific MHC I alleles to maintain tolerance to self tissues, and NK activation
This chapter describes the techniques our lab has used to find the multiple promoters present in individual KIR genes. Our previous studies in the murine Ly49 gene family led us to expect the presence of distal promoters, antisense
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