- ￥598 - 2488
- abinScience
- France
- HC336026
- 2026年04月13日
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Human
- Human
企业认证
相关产品推荐更多 >
Anti-DENV-1/2/3/4 Envelope protein E/EDIII A strand Antibody (4E11#)
￥1338
KRT76 Polyclonal Antibody（多克隆抗体）, HRP conjugated | KRT76 Antibody, HRP conjugated | KRT76抗体, HRP conjugated
￥880
ZFR Polyclonal Antibody（多克隆抗体） | ZFR Antibody | ZFR抗体
￥880
ALAS2 Polyclonal Antibody（多克隆抗体）, Biotin conjugated | ALAS2 Antibody, Biotin conjugated | ALAS2抗体, Biotin conjugated
￥880
Anti-Human glyco-MUC4 Antibody (2D5)
￥1338
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG4-kappa
- 形态：
Liquid
- 保存条件：
-20°C
- 克隆性：
单克隆
- 适应物种：
Human
- 保质期：
12 months
- 级别：
一抗
- 供应商：
武汉研升生物科技有限公司
- 宿主：
Human
- 应用范围：
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- 抗体英文名：
Research Grade Urelumab
- 规格：
100μg/1mg
| 规格： | 100μg | 产品价格： | ￥598.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥2488.0 |
| 产品名 | Research Grade Urelumab |
| 货号 | HC336026 |
| 别名 | BMS-663513, 934823-49-1 |
| 表达系统 | Mammalian Cells |
| 靶标 | Tumor necrosis factor receptor superfamily member 9, CD137, 4-1BB ligand receptor, CDw137, TNFRSF9, T-cell antigen ILA, T-cell antigen 4-1BB homolog, ILA |
| Accession号 | Q07011 |
| 宿主 | Human |
| 种属反应性 | Human |
| 克隆性 | Monoclonal |
| 同种型 | IgG4-kappa |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 状态 | Liquid |
| 背景 | Urelumab is a fully humanized agonistic monoclonal antibody targeting the CD137 receptor with potential immunostimulatory and antineoplastic activities. Urelumab specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. Urelumab has been used in trials studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and Cancer-Solid Tumors and B-Cell Non-Hodgkin's Lymphoma. The antibody product was developed using Medarex's UltiMAb(R) technology and was the first UltiMAb-derived antibody in clinical development by Bristol-Myers Squibb under the December 2003 agreement with Medarex. In December 2008, enrolment was stopped for all urelumab studies following the occurrence of two hepatotoxicity-related deaths. Several years later, the clinical study on Urelumab was restarted. At present, the approval of the monoclonal antibody has not been disclosed in the relevant drug approval agency. • Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB., PMID:9045669 • ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages., PMID:7849293 • CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes., PMID:10607752 • CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling., PMID:9498794 • A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis., PMID:9485208 • CD137-induced apoptosis is independent of CD95., PMID:10469232 • CD137 activation abrogates granulocyte-macrophage colony-stimulating factor-mediated anti-apoptosis in neutrophils., PMID:11093162 • Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: modulation by FGF-2., PMID:13130507 • Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation., PMID:10873573 • CD137 expression in tumor vessel walls. High correlation with malignant tumors., PMID:11293902 |
| 保存溶液 | 0.94 mM Citricacid, 16.7mM Trisodiumcitratedihydrate, 6.2% sucrose, pH 6.5, 0.01% Tween80 |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 说明 | For research use only. Not suitable for clinical or therapeutic use. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Characterization and Quality Control of Antibodies Used in ChIP Assays
epigenetics research tools based on everyday’s researcher’s needs by providing batch-specific fully characterized ChIP-grade antibodies.
相关专题 his method was successful in our lab using prostate tissue and for our specific objectives. Investigators must be aware that they will need to tailor the following protocol for their own research objectives
®尤其在皮肤组织的表皮分离和上皮层细胞培养中获得了广泛的应用。Dispase®I与Dispase®II两者的差别在于纯度的不同，Dispase®I经过滤除菌，且每mg Dispase®I的纯度和酶活远高于Dispase®II。 罗氏高纯度研究级别酶混合物Liberase Research Grade Enzyme Blends Liberase Research Grade Enzyme Blends包含了一系列酶混合物，它们由不同比例的中性蛋白酶（非梭菌蛋白酶）和高纯
技术资料暂无技术资料 索取技术资料
