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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
PD-L1抗体
- 免疫原:
Mouse IgG2b, κ
- 亚型:
29E.2A3
- 级别:
InVivoMab Antibodies
- 抗原来源:
人,大小鼠
- 应用范围:
in vitro PD-L1 blockade Functional assays Immunohistochemistry (frozen) Flow cytometry
- 是否单克隆:
单克隆
- 抗体英文名:
nVivoMAb anti-human PD-L1 (B7-H1)
- 适应物种:
人
- 抗原:
29E.2A3
- 规格:
1mg
PD-L1抗体
Bio X cel公司l通过大规模的组织培养生产抗体,亲和层析法纯化抗体,我们提供的抗体都是高纯度、低内毒素,无防腐剂和稳定剂,适用于临床前研究
| Isotype | Mouse IgG2b, κ |
| Recommended Isotype Control(s) | InVivoMAb mouse IgG2b isotype control, unknown specificity(BE0086) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | Full length human PD-L1 |
| Reported Applications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
BioXcell BE0285-50MG InVivoMab anti-human PD-L1 (B7-H1) ¥24000
BioXcell BE0285-100MG InVivoMab anti-human PD-L1 (B7-H1) ¥35200
BioXcell BE0285-1MG InVivoMab anti-human PD-L1 (B7-H1) ¥1520
BioXcell BE0285-5MG InVivoMab anti-human PD-L1 (B7-H1) ¥5600
BioXcell BE0285-25MG InVivoMab anti-human PD-L1 (B7-H1) ¥14400
About InVivoMAb anti-human PD-L1 (B7-H1)
The 29E.2A3 monoclonal antibody reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. The 29E.2A3 antibody has been shown to block the binding of PD-1-Ig to PD-L1.
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文献和实验了 B7 家族的第三个成员 B7-H1(即日后的 PD-L1)[2]。2000 年,Tasuku Honjo 教授等人证明了 PD-L1 能与 PD-1 结合,进而抑制 T 细胞的增殖与细胞因子的分泌,负调控淋巴细胞的激活,从此,B7-H1 被正式命名为 PD-L1(陈列平教授则继续使用「B7-H1」命名)[3]。2003年,陈列平教授第一次成功地使用 PD-L1 封闭抗体联合 T 细胞回输技术治愈了约 60% 的头颈癌小鼠[4]。2014 年 12 月,首个应用于肿瘤治疗的抗 PD-1 抗体
: CSB-BP619964 HU >> Baculovirus CSB-MP619964 HU >> Mammalian cell PD1 多克隆抗体 Rabbit anti PD1 货号:CSB-PA619964LA01 HU 识别种属:human,mouse 应用检测:WB、IHC、IF 等 TIM3 重组蛋白 货号:CSB-EP010145 HU TIM3 多克隆抗体
被 PeterLinsley 鉴定,而且免疫抑制功能也是在 1994 年被 Jeffrey Bluestone 发现。但Allison 始终对外宣称他是发明了 CTLA-4 抗体治疗肿瘤的。James Allison 与他自己牌照为CTLA-4的保时捷 911 跑车而陈列平教授率先克隆并鉴定了 B7-H1 分子(即现在的 PD-L1)做出的开创工作(1999 年)。陈列平教授率先证明了 B7-H1 蛋白在许多人肿瘤里大量地表达,为临床试验奠定基础(2002 年)。Tasuku Honjo 这时才开始了解到 10 年前
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