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- ALX-620-053
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- 2026年03月04日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
少量现货
- 英文名：
JC-1 . iodide
- CAS号：
47729-63-5
- 保质期：
As indicated on product label or CoA when stored as recommended.
- 供应商：
欣博盛生物
- 保存条件：
+4°C
- 规格：
5 mg
JC-1 . iodide产品货号ALX-620-053，由ENZO公司研发生产，欣博盛生物是ENZO公司授权一级代理商，如需购买ENZO公司产品，技术问题，请联系欣博盛生物。热销品常备现货~
JC-1 is a very sensitive fluorescent probe to test Pgp activity. In acute myeloid leukemia (AML) samples JC-1 is capable of distinguishing between resistant, intermediate and sensitive groups, whereas rhodamine 123 only recognizes the resistant group. As in cell lines, the red emission band (597nm) of JC-1 appears to be more convenient for detection of low-level resistance in AML than other probes, such as rhodamine 123 (529nm) or calcein-AM (517nm). Green fluorescent JC-1 existing as a monomer (λem=527nm) at low concentrations or at low membrane potential. However, at higher concentrations (aqueous solutions above 0.1µM) or higher potentials, JC-1 forms red fluorescent ‘J-aggregates’, which exhibit a broad excitation spectrum and a very narrow emission spectrum (λem=590nm). JC-1 stains mitochondria in living cells in a membrane potential-dependent function. JC-1 has been used in a functional assay of multidrug resistance cells and in apoptosis related mitochondrial modifications.
Product Details
Alternative Name
5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide
Appearance
Red solid.
CAS
47729-63-5
Formula
C25H27Cl4IN4
MW
652.2
Purity
≥98% (HPLC)
Solubility
Soluble in DMSO or methanol.
Handling & Storage
Use/Stability
As indicated on product label or CoA when stored as recommended.
Handling
Protect from light, especially when in solution. Keep cool and dry.
Long Term Storage
+4°C
Shipping
Ambient Temperature
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文献和实验- Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline: P. Jadiya, et al.; iScience 26, 106296 (2023), Abstract
- Impact of in vitro digested zinc oxide nanoparticles on intestinal model systems: A. Mittag, et al.; Part. Fibre Toxicol. 19, 39 (2022), Abstract
- p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction: C. Dinhof, et al.; Cancers (Basel) 12, 3205 (2020), Abstract — Full Text
- Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy: P. Zhou, et al.; Cells 8, 213 (2019), Application(s): Measuring Mitochondrial membrane potential of rMC-1 cells in flow cytometry, Abstract — Full Text
- Tanshinone IIA induces apoptosis via inhibition of Wnt/β‑catenin/MGMT signaling in AtT‑20 cells: Z.Y. Li, et al.; Mol. Med. Rep. 16, 5908 (2017), Abstract — Full Text
- Popdc1/Bves Functions in the Preservation of Cardiomyocyte Viability While Affecting Rac1 Activity and Bnip3 Expression: V. Kliminski, et al.; J. Cell Biochem. 118, 1505 (2017), Abstract
- Metformin protects kidney cells from insulin mediated genotoxicity in vitro and male Zucker diabetic fatty rats: E.M. Othman, et al.; Endocrinology 157, 548 (2016), Application(s): Cell culture, Abstract — Full Text
- Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells: M.K. Pal, et al.; Eur. J. Pharmacol. 791, 751 (2016), Application(s): JC-1 staining for mitochondrial membrane potential nuclear integrity assay, Abstract
- Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of c6 glioma cells by inhibiting glycolysis: C. Wang, et al.; Cancer Lett. 378, 1 (2016), Application(s): Used to measure mitochondrial membrane potential, Abstract
- Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line: D. Chopra, et al.; Biomaterials 84, 25 (2016), Application(s): Cell staining, Abstract
线粒体荧光探针大全：TMRM，Mitotracker，JC-1
-fluorescent JC-1 probe (5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide, T3168; Figure 22.13) exists as a monomer at low concentrations or at low membrane potential. However, at higher concentrations (aqueous solutions above 0.1 µM
线粒体跨膜电位DYmt的下降，被认为是细胞凋亡级联反应过程中最早发生的事件，它发生在细胞核凋亡特征（染色质浓缩、DNA断裂）出现之前，一旦线粒体DYmt崩溃，则细胞凋亡不可逆转。 线粒体跨膜电位的存在，使一些亲脂性阳离子荧光染料如Rhodamine 123、3，3-Dihexyloxacarbocyanine iodide[DiOC6（3）]、Tetrechloro-tetraethylbenzimidazol carbocyanine iodide[JC-1]、Tetramethyl
Flow Cytometric Methods for Sperm Assessment
) for assessing sperm viability; the double stain PNA-FITC (peanut agglutinin-fluorescein isothiocyanate) and PI for assessing acrosomal integrity combined with sperm viability; and JC-1 (5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-benzimidazolylcarbocyanine iodide
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