- ￥3093 - 8543
- Enzo
- ENZ-51018
- 美国
- 2026年03月04日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
少量现货
- 英文名：
MITO-ID® Membrane potential detection kit
- CAS号：
/
- 保质期：
见包装说明
- 供应商：
欣博盛生物
- 保存条件：
-80°C
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥3093.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥8543.0 |
MITO-ID® Membrane potential detection kit产品货号ENZ-51018，由ENZO公司研发生产，欣博盛生物是ENZO公司授权一级代理商，如需购买ENZO公司产品，技术问题，请联系欣博盛生物。热销品常备现货~
- Dual-emission dye fluoresces either green or orange depending upon mitochondrial membrane potential status
- 10X more sensitive than JC-1 with superior aqueous solubility
- True mix-and-read homogeneous assay for live cells
- Suitable for chemical/environmental toxicity screening
- Optimized for fluorescence microscopy, flow cytometry and microplate reader
- Suitable for high-throughput applications
Enzo Life Sciences MITO-ID® Membrane Potential Detection Kit is a mitochondria tracker dye including a dual-emission cationic dye. It measures the mitochondrial membrane potential (MMP) in live cells. In energized or active cells, the MITO-ID® Membrane Potential dye rapidly accumulates as orange-fluorescent aggregates in the mitochondria due to their relative negative charge, while it exists as a green-fluorescent monomer in the cytosol. However, in cells with compromised MMP, the MITO-ID® Membrane Potential dye exists primarily as green-fluorescent monomers throughout the cytosol and no longer exhibits orange fluorescence in the mitochondria. A widely used uncoupler of mitochondrial oxidative phosphorylation (CCCP) is provided as a positive control for monitoring loss in mitochondrial membrane potential.
Cell-based assays for evaluating the functional status of mitochondria are useful tools for elucidating the role of mitochondrial activity in drug-induced toxicity, the apoptosis cascade and other cellular and biochemical processes. The loss of the mitochondrial membrane potential (MMP) is often associated with early stages of apoptosis. The collapse of MMP coincides with the opening of the mitochondrial permeability transition pores, leading to the release of cytochrome C into the cytosol, which in turn triggers other downstream events in the apoptotic cascade.
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MitoProbe DiIC1 Mitochondrial Membrane Potential Protocol
(V13241, prepared according to instructions accompanying that kit). 5) Incubate the samples at 37°C for 15 minutes. (37°C is important to maintain membrane potential.) 6) Add 400 μL annexin binding buffer. 7) Analyze
Fluorometric Methods for Detection of Mitochondrial Membrane Permeabilization in Apoptosis
a step-by-step manual for the measurements of the mitochondrial membrane potential, retention of Ca2+ and cytochrome c , matrix volume, and caspase activation and discusses protocols for discrimination between different mechanisms of the OMM
of the cell ( 1 , 2 ). Fig. 1. Forces that regulate and determine membrane potential. Approximate intracellular and extracellular ion concentrations for mammalian cells are represented in boxes. White arrows represent direction and strength
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