- ￥2149.85 - 6643.73
- Enzo
- ALX-302-011
- 美国
- 2026年03月03日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
少量现货
- 英文名：
Ganglioside GT1b . trisodium salt (bovine brain)
- CAS号：
/
- 保质期：
As indicated on product label or CoA when stored as recommended.
- 供应商：
欣博盛生物
- 保存条件：
-20°C
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2149.85 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥6643.73 |
Ganglioside GT1b . trisodium salt (bovine brain)产品货号ALX-302-011，由ENZO公司研发生产，欣博盛生物是ENZO公司授权一级代理商，如需购买ENZO公司产品，技术问题，请联系欣博盛生物。热销品常备现货~
Brain ganglioside
Highly pure Ganglioside GQ1b isolated from bovine brain
Used for the differentiation of a variety of cells
Gangliosides consist of a ceramide moiety, an oligosaccharide head group, and one or more sialic acids. They are involved in a variety of cellular functions acting as cell adhesion receptors and immunological receptors via the binding of lectins; contributing to cell differentiation, cell signaling, and oncogenesis; participating in myelin stability and nerve regeneration; and operating as an entry point for toxins and viruses. Ganglioside GT1b consists of a tetra-saccharide core with two sialic acid on the internal galactose and an extra sialic acid on the non-reducing terminal galactose. Ganglioside GT1b prevents neurotoxicity of glutamate on neuronal cells and binds to the neurotoxins Botulinum Toxin serotype A (BTxA), BTxA heavy chain, and Tetanus Toxin with respective IC50 values of 11, 0.74, and 7.2 µM. Treatment of human PBMC with Ganglioside GT1b is associated with a decrease in IgA, IgG, IgM, IL-6, and IL-10 levels.
Product Details
Alternative Name
GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain)
Appearance
White solid.
Couple Target
Clostridium botulinum, Clostridium tetani
Formula
C95H162N5O47 . 3Na
Identity
Confirmed by MS.
MW
2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)
Purity
≥98% (TLC)
Sequence
[II3(Neu5Ac)2, IV3(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1′)-Cer]
Solubility
Soluble in chloroform/methanol/DI water, 2:1:0.1; forms micellar solution in water.
Source
Bovine brain
Handling & Storage
Use/Stability
As indicated on product label or CoA when stored as recommended.
Handling
Protect from moisture.
Long Term Storage
-20°C
Shipping
Ambient Temperature
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文献和实验- A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA: D.C. Rupp, et al.; Clin. Cosmet. Investig. Dermatol. 16, 581 (2023), Abstract
- Anti-inflammatory role of GM1 and other gangliosides on microglia: D. Galleguillos, et al.; J. Neuroinflammation 19, 9 (2022), Abstract — Full Text
- Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay: N.G. James, et al.; Sci. Rep. 11, 7832 (2021), Abstract — Full Text
- A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer’s disease mice: Q. Guo, et al.; J. Control Release 320, 347 (2020), Abstract
- Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol: B.J. Pavlik, et al.; Sci. Rep. 6, 23707 (2016), Abstract — Full Text
- GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons: E.S. Chung, et al.; BMC Neurosci. 11, 74 (2010), Abstract
- Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex: M. Favaron, et al.; PNAS 85, 7351 (1988), Abstract
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