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文献和实验Tumor necrosis factor (TNF) is a pleiotropic cytokine that signals inflammation as well as cell death. We focus herein on the inflammatory pathway, giving particular emphasis to the in vitro methods used to study intracellular signaling mediators
, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation
in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK kinases and activation of ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT
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