- ￥1900
- Biorigin
- BN41402R
- 2026年02月24日
- WB,
- Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,
- 应用范围：
WB,
- 抗体英文名：
CHPT1
- 规格：
100ul
| 英文名称 | CHPT1 |
| 中文名称 | 甘油二酯胆碱磷酸转移酶抗体 |
| 别 名 | AAPT1-like protein; Cholinephosphotransferase 1; chpt1; CHPT1_HUMAN; Diacylglycerol cholinephosphotransferase 1; hCPT1. |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CHPT1:61-160/406 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | CHPT1, also known as AAPT1-like protein and Diacylglycerol cholinephosphotransferase 1, is a 406 amino acid multi-pass membrane protein that is localized to the golgi apparatus. By catalyzing the phosphatidylcholine biosynthesis from CDP-choline, it plays an essential role in the formation and maintenance of vesicular membranes. CHPT1 is most abundant in testis, as well as small intestine, heart, colon, spleen and prostate. Expression of CHPT1 is increased in cancerous breast cells as compared to normal breast cell lines and it has been determined that the CHPT1 gene exhibits mutations within the cancerous cells. Interestingly, exposure to mustard gas significantly decreases CHPT1 gene expression and activity, an event that may play an important role in the development of acute respiratory distress syndrome (ARDS). There are two isoforms of CHPT1 that are produced as a result of alternative splicing events. Function: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes. Subcellular Location: Golgi apparatus membrane. Tissue Specificity: Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines. Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family. SWISS: Q8WUD6 Gene ID: 56994 Database links: Entrez Gene: 56994 Human SwissProt: Q8WUD6 Human Unigene: 293077 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验）、棕榈二油酸甘油酯（ palmitodio－ lein）等。在甘油二酯、甘油单酯中，位于甘油的 2位的脂肪酸容易转移到 1位，为脂酶水解而游离出脂肪酸。生物合成途径有如下两类：甘油磷酸途径（Ⅰ）和甘油单酯途径（Ⅱ）。 （Ⅰ）甘油磷酸途径： （ 1）甘油磷酸酰基转移酶（ EC2． 3． 1． 15） （ 2）磷脂酸磷酸酶（ 3． 1． 3． 4） （ 3）甘油二酯酰基转移酶（ 2． 3． 1．
亦称为胆碱磷酸，是动物细胞中卵磷酯生物合成的中间体。通过动物，酵母中的胆碱激酶从胆碱和 ATP生成磷酸胆碱和 ADP。其 Mg盐可用于治疗肝胆液分泌障碍。与 CTP一起，由磷酸胆碱胞嘧啶苷转移酶的作用生成 CDP胆碱。
磷酯酰乙醇胺 phosphatidyl ethanolamine
的脱羧作用形成的。在动物中，它是通过 CDP乙醇胺和 1， 2-甘油二酯的反应生成的。通过磷酯酶 A的作用生成溶血磷酯酰乙醇胺。据很道，在老鼠肝脏中，它与卵磷酯一起在微粒体，线粒体间进行转移。
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