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Recombinant Human Ezrin/EZR/VI

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  • ¥840 - 2520
  • 近岸蛋白(Novoprotein)已认证
  • 中国
  • CH43
  • 2026年02月13日
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      Recombinant Human Ezrin/EZR/VIL2

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥840.0
    规格:50ug产品价格:¥2520.0
    规格:500ug产品价格:询价
    规格:1mg产品价格:询价

    Recombinant Human Ezrin/EZR/VIL2  (CH43)

     

    产品说明(Description)

    Recombinant Human Ezrin is produced by our E.coli expression system and the target gene encoding Met1-Leu586 is expressed. 

    Accession #: P15311

    Known as: Ezrin; Cytovillin; Villin-2; p81; EZR; VIL2

     

    制剂(Formulation)

    Supplied as a 0.2 μm filtered solution of 10mM Hepes, pH7.4.

     

    质量控制(Quality Control) 

     

    Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

    Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

     

     

    运输(Shipping)

    The product is shipped on dry ice/polar packs. 
    Upon receipt, store it immediately at the temperature listed below.

     

    保存(Storage)

    Store at ≤-70°C, stable for 6 months after receipt.
    Store at ≤-70°C, stable for 3 months under sterile conditions after opening. 
    Please minimize freeze-thaw cycles.   

     

    背景(Background)

    Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.

     

    电泳(SDS-PAGE)

     

    参考文献(Reference)

    1、The combination of dendritic cells-cytotoxic T lymphocytes/cytokine-induced killer (DC-CTL/CIK) therapy exerts immune and clinical responses in patients with malignant tumors. Wang Y. et al. Experimental hematology & oncology. 2015.

     

     

    FOR RESEARCH USE ONLY

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