Alexa Fluor® 647 anti-human CD

Clone

L3D10

Regulatory Status RUO

Other Names Cytotoxic T-Lymphocyte Antigen 4

Isotype Mouse IgG1, κ

Description CD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the

immunoglobulin superfamily. It is transiently expressed on activated T cells. CTLA4 is

expressed on the surface of helper T cells and transmits an inhibitory signal to T cells.

Regulatory T cells express high levels of CTLA-4. CTLA-4 (CD152) is similar to CD28 in amino

acid sequence, structure, and genomic organization. Whereas CD28 delivers a costimulatory

signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses

through interaction with CD80 (B7-1) and CD86 (B7-2) present on antigen presenting cells

(APC). CTLA-4 is thought to play a role in the induction and maintenance of immunological

tolerance as well as the development of protective immunity and thymocyte regulation.

Mutations in the CTLA-4 gene have been associated with various autoimmune diseases, such

as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune

diseases. A transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4

(sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD) had

a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers

contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1,

suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial

immune response to infection of immune cells by HIV, along with the CD-1 pathway and

others.