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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
Purified anti-mouse TCR γ/δ
- 抗体英文名:
Purified anti-mouse TCR γ/δ
- 浓度:
0.5 mg/mL
- 应用范围:
免疫荧光,流式
- 宿主:
Armenian Hamster
- 供应商:
上海善然生物
- 库存:
现货
- 抗原来源:
Armenian Hamster
- 保质期:
2-3年左右
- 适应物种:
小鼠
- 标记物:
Purified
- 克隆性:
单克隆
- 保存条件:
2-8度
- 形态:
液体
- 规格:
500 μg
Purified anti-mouse TCR γ/δ Antibody
UC7-13D5
Catalog# / Size 107502 / 500 µg
Clone
Regulatory Status RUO
Other Names TCR-γ/δ, γ/δ TCR
Isotype Armenian Hamster IgG
Description T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a
δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the
recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ
associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal
epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are
CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role
in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported
that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5
antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete
peripheral TCR-γ/δ-bearing T cells in vivo.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Armenian Hamster
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C.
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文献和实验更多产品详细信息欢迎来电咨询~周祥15900853496微信同号,汪海洋15901695283微信同号
癌 (NCT00562666)、肾癌[19,20]、乳腺癌[21]、前列腺癌[10]、神经母细胞瘤[21]和肺癌[23,24]等。这些临床研究证实了γδ T细胞的过继性转移是安全可行的[25]。 而本文开头提到的Adicet Bio公司正在开发的产品通过anti-CD20 CAR和γδ T细胞内源性细胞毒性受体靶向恶性B细胞,在临床前模型中表现出高效的抗肿瘤活性,有效地控制了肿瘤的生长。 图3. Adicet基于γδ T细胞的细胞疗法流程(图片来源于Adicet官网) 目前γδ T细胞疗法面临的最大阻碍包括
1.1 材料和仪器RPMI-1640(Gibco公司产品),人AB血清来自徐州市血站,胎牛血清和淋巴细胞分离液购自中国科学院血液病研究所,异戊烯焦磷酸(isopentenylpgrophosphate.IPP)购自sigma公司,IL-2(夏门),抗人TCR-γδ-FITC,抗人CD3Ab-PE,抗人CD44Ab-FITC,均购自杭州联科生物(Immutech,French),K562细胞和SGC-7901胃腺癌细胞由中国科学院上海细胞所提供,流式细胞分析仪(FACSC alibur.Becton
【进展|热点】Immunity: γδ T细胞抑制调节性T细胞
γδ T细胞抑制调节性T细胞 文章出处:γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism. Immunity. 2010. 33:351-363 主要内容: T细胞根据其TCR链的不同可以分为αβ T细胞和γδ T细胞两类,前者是经典的T细胞,我们常规提到的T细胞指的就是αβ T细胞。γδ
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