PE anti-human CD156c (ADAM10)

Clone

SHM14

Regulatory Status RUO

Other Names MADM, KUZ, alpha-secretase

Isotype Mouse IgG1, κ

Description CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10

(ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most

cell types. It consists of multiple functional domains, including a N-terminal prodomain,

catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It

is secreted as a precursor protein and becomes as the activate/mature form through removing

the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as

metalloproteinase to cleave several molecules including Notch, pro-TNF-α, amyloid precursor

protein, myelin basic protein, and type IV collagen. It mediates the release of several cell

adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial

permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to

the pathogenesis of vascular diseases.