Alexa Fluor® 594 anti-mouse CD

Alexa Fluor® 594 anti-mouse CD8a Antibody
53-6.7
Catalog# / Size 100758 / 100 µg
Clone
Regulatory Status RUO
Other Names T8, Lyt2, Ly-2
Isotype Rat IgG2a, κ
Description CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the
α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the
immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and
a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4.
The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal
intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that
interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell
activation through its association with the TCR complex and protein tyrosine kinase lck.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Mouse thymus or spleen
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal
conditions.
Concentration 0.5 mg/mL
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged
exposure to light. Do not freeze.
Application IHC-F - Quality tested
FC, 3D IHC - Verified