- ￥3640
- biorbyt
- 英国
- orb2658410
- 2025年12月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
- 保质期：
6个月
- 英文名：
Recombinant Mouse Adenosine deaminase (Ada)
- 库存：
详询客服
- 供应商：
biorbyt
- 规格：
20 ug
产品别名：Adenosine aminohydrolase
应用笔记：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
纯度：Greater than 95% as determined by SDS-PAGE.
生物来源：Mus musculus (Mouse)
蛋白序列：AQTPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ
分子量：46.8 kDa
表达区域：2-352aa
标签：C-terminal 6xHis-tagged
防腐剂：If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
来源：E.coli
形态：Liquid or Lyophilized powder
Uniprot ID：P03958
Note：For research use only.
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文献和实验免疫的联合缺陷，对各种病原生物都易感，临床上常发生反复肺部感染、口腔念珠菌感染、慢性腹泻、败血症等。在治疗方面可选用正常骨髓干细胞移植或同胞兄妹骨髓移植。但供体骨髓中T细胞介导的移埴物抗宿主反应（GVH）往往是造成治疗失败的严重问题。 约有25％～50％的重症联合免疫缺陷病例，主要与先天性缺乏腺苷脱氨酶（adenosine deaminase，ADA）有关。一则严重影响细胞DNA包括淋巴细胞DNA的合成代谢，同时由于三磷酸脱氧腺苷在淋巴细胞的堆积，后者对淋巴细胞尤其是T细胞具有一定的毒性
和核苷酸水平上分别由腺苷脱氨酶(adenosine deaminase,ADA)和腺苷酸脱氨酸(AMP deaminase)催化脱氨生成次黄嘌呤核苷或次黄嘌呤核苷酸。它们再水解成次黄嘌呤，并在黄嘌呤氧化酶(xanthine oxidase)的催化下逐步氧化为黄嘌呤和尿酸(uric acid)。ADA的遗传性缺乏，可选择性清除淋巴细胞，导致严重联合免疫缺陷病(Severe combined immunodeficiency olisease,SCID)。 体内嘌呤核苷酸的分解
【交流】复旦学子报道高剂量siRNA在小鼠中可以抑制RNAi
of siRNA, and the rebound was associated with an increase in the mRNA level of meri-1 (mouse enhanced RNAi) and adar-1 (adenosine deaminase acting on RNA) genes encoding an exonuclease and RNA-specific adenosine deaminase respectively. Down-regulation
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