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谱度众合(武汉)生命科技有限公司位于光谷生物城，是一家由武汉大学校友团队创办的国家高新技术企业，明确提出临床蛋白质组学概念，并系统性将蛋白质组学技术应用于各个临床科室(如:心内科、血液内科、胸外科、泌尿外科、口腔科、神经科、感染科、麻醉科等)的“专精特新企业”
依托谱度众合人才团队建成的基于蛋白质组学技术的“生物标志物发现与药物靶点筛选平台”，在2023年被认定为“国家生物产业基地公共服务平台”(光谷生物城15年间仅17个平台获此资质)以及“武汉市科技成果转化中试平台”，是华中地区非常优质的蛋白质组学平台。
围绕该平台已成功布局专利技术30余项、发表SCI论文100余篇、获批国家及省市基金10余项。目前该平台已服务客户2000余名，遍布全国各大科研院所，尤其聚焦医学客户。平台服务速度快、数据质量高，客户发表的SCI论文中，从样本送检到论文见刊，周期最短的仅6个月。
凭借雄厚的技术实力，在新冠疫情期间，平台研发人员与张定宇院长等团队合作，通过血浆蛋白质组学检测，对新冠肺炎患者的病情严重程度进行了精准预测，该成果发表在免疫学TOP期刊Immunity(IF=43.474)上，谱度众合为该论文共同第一作者单位。
作为医学蛋白质组学领域的引领者，谱度众合充分考虑医学研究的实际需求，为客户提供一站式科研服务(从方案设计到报告生成)，帮助客户顺利完成论文发表和基金申请。
谱度众合蛋白质组学研究的核心优势
- 倍增效率：区别于一般组学平台仅提供检测数据，我们针对特定研究目的开发Zui优解决方案(例如互作蛋白筛选、药物靶点筛选等)，帮助客户提高实验成功率2倍以上；
- 科班出身：由武汉大学生科院蛋白质组学课题组博士师兄弟组建的技术型团队，人均发表组学相关中科院2区以上SCI论文20余篇，在组学专业领域持续深耕20年；
- 技术先进：专注优势领域，与国内优质科研院所合作建立企校联合创新中心，持续开发组学相关前沿技术，累计投入研发费用超过2000万元布局专利技术50余项。
谱度众合服务案例：公司产出数据发表的论文(署名/致谢)达到200+篇，影响因子2000+。其中2024年50+篇，双一区32篇，平均IF=9.819，累计IF=520.4。
| 序号 | 文章标题 | 期刊 | 分区 | 影响因子 | 发表时间 |
| 1 | TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway | Journal of Hepatology | Q1/医学1区 | 33 | 2025 |
| 2 | The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity | Nature Immunology | Q1/医学1区 | 27.7 | 2025 |
| 3 | A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis | Gut | Q1/医学1区 | 25.8 | 2025 |
| 4 | ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation | Gut | Q1/医学1区 | 25.8 | 2025 |
| 5 | Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma | Cancer Communications | Q1/医学1区 | 24.9 | 2025 |
| 6 | Selective and Potent Molecular Glue Degraders for NIMA-related Kinase 7 | Angewandte Chemie-International Edition | Q1/化学1区 | 16.9 | 2025 |
| 7 | NEK7 induced phosphorylation of EGFR on serine 1070 drive the acquired lenvatinib resistance in hepatocellular carcinoma | Hepatology | Q1/医学1区 | 15.8 | 2025 |
| 8 | PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses | Nature Communications | Q1/综合1区 | 15.7 | 2025 |
| 9 | Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy | Nature Communications | Q1/综合1区 | 15.7 | 2025 |
| 10 | Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA | Nature Communications | Q1/综合1区 | 15.7 | 2025 |
| 11 | ATOH8 confers the vulnerability of tumor cells to ferroptosis by repressing SCD expression | Cell Death and Differentiation | Q1/生物学1区 | 15.4 | 2025 |
| 12 | MYSM1 attenuates osteoarthritis by recruiting PP2A to deubiquitinate and dephosphorylate RIPK2 | Bone Research | Q1/医学1区 | 15 | 2025 |
| 13 | Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration | Bone Research | Q1/医学1区 | 15 | 2025 |
| 14 | Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype | Acta Pharmaceutica Sinica B | Q1/医学1区 | 14.6 | 2025 |
| 15 | USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation | J Extracell Vesicles | Q1/医学1区 | 14.5 | 2025 |
| 16 | Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration | Autophagy | Q1/生物学1区 | 14.3 | 2025 |
| 17 | BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING | Advanced Science | Q1/综合1区 | 14.1 | 2025 |
| 18 | EBBP-Mediated Integrated Stress Response Attenuates Anthracycline-Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes | Advanced Science | Q1/综合1区 | 14.1 | 2025 |
| 19 | Restoration of SIRT3 Expression in Aged Mice Alleviates UUO-Induced Renal Fibrosis by Reducing GSK-3β Hyperacetylation | Advanced Science | Q1/综合1区 | 14.1 | 2025 |
| 20 | Branched-Chain α Keto-Acid Dehydrogenase Kinase-Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance | Advanced Science | Q1/综合1区 | 14.1 | 2025 |
| 21 | Targeting RBM10-Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF-κB Signaling | Advanced Science | Q1/综合1区 | 14.1 | 2025 |
| 22 | A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer | Advanced Science | Q1/综合1区 | 14.1 | 2025 |
| 23 | Microrchidia ATPases and DNA 6mA demethylase ALKBH1 act antagonistically on PRC2 to control chromatin structure and stress tolerance | Nature Plants | Q1/生物学1区 | 13.6 | 2025 |
| 24 | FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma | Theranostics | Q1/医学1区 | 13.3 | 2025 |
| 25 | Mesenteric adipose-derived exosomal TINAGL1 enhances intestinal fibrosis in Crohn's Disease via SMAD4 | Journal of Advanced Research | Q1/综合1区 | 13 | 2025 |
| 26 | Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling | Journal of Advanced Research | Q1/综合1区 | 13 | 2025 |
| 27 | SNORA37/CMTR1/ELAVL1 feedback loop drives gastric cancer progression via facilitating CD44 alternative splicing | Journal of Experimental & Clinical Cancer Research | Q1/医学1区 | 12.8 | 2025 |
| 28 | Targeting ecircOGT/OGT/FOXC1 axis inhibits asparagine and alanine-mediated ferroptosis repression in neuroblastoma progression | Research | Q1/综合1区 | 10.7 | 2025 |
| 29 | Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression | Research | Q1/综合1区 | 10.7 | 2025 |
| 30 | Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4 | MedComm | Q1/医学1区 | 10.7 | 2025 |
| 31 | ALK2/3 recruitment to the immunological synapse is required for T cell activation and death | Journal of Experimental Medicine | Q1/医学1区 | 10.6 | 2025 |
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文献和实验1. Dong R, Wang T, Dong W, et al. TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway. J Hepatol. 2025;83(1):105-118. doi:10.1016/j.jhep.2024.12.038
2. Xiang B, Zhang M, Li K, et al. The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity. Nat Immunol. 2025;26(2):252-264. doi:10.1038/s41590-024-02047-w
3. Chen Y, Li W, Wang S, et al. A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis. Gut. Published online November 4, 2025. doi:10.1136/gutjnl-2025-336363
4. Yuan Y, Li J, Rao D, et al. ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation. Gut. Published online November 14, 2025. doi:10.1136/gutjnl-2025-335327
5. Zhu J, Xiong Y, Zhang Y, et al. Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma. Cancer Commun (Lond). 2025;45(8):1038-1071. doi:10.1002/cac2.70036
6. Chen L, Huang L, Wen W, et al. Selective and Potent Molecular Glue Degraders for NIMA-Related Kinase 7. Angew Chem Int Ed Engl. 2025;64(12):e202500169. doi:10.1002/anie.202500169
7. Huang Q, Wang W, Ge Q, et al. NEK7-induced phosphorylation of EGFR on serine 1070 drives the acquired lenvatinib resistance in hepatocellular carcinoma. Hepatology. Published online July 22, 2025. doi:10.1097/HEP.0000000000001474
8. Shi M, Wang C, Chen Z, et al. PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses. Nat Commun. 2025;16(1):4084. Published 2025 May 1. doi:10.1038/s41467-025-59421-x
9. Chen D, Zhao Z, Hong R, et al. Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy. Nat Commun. 2025;16(1):4128. Published 2025 May 3. doi:10.1038/s41467-025-59318-9
10. Yang W, Li H, Wang S, et al. Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA. Nat Commun. 2025;16(1):6756. Published 2025 Jul 22. doi:10.1038/s41467-025-62044-x
、周期长的问题，代谢组学的应用降低了风险，缩减了周期，可高通量、系统性地筛选、评价化学合成的化合物，天然活性物质等，以获得新的生物活性物质作为潜在药物，从而为新药的筛选和鉴定提供更多的选择和思路。 药物作用机制研究：代谢组学结合药代动力学的研究，是目前发展最为成熟的药物作用机制研究思路，代谢组学可系统地研究药物引起的内源性代谢物变化，药物本身的代谢和动力学变化，更客观直接地反映药物作用下生物机体本身的生化过程和状态的变化。 药物毒理研究：代谢组学的出现为药物毒理学发展赋予了新的契机
代谢组学的研究目标是尽可能对生物系统中所有代谢物进行定性和定量的分析，是研究代谢物谱、代谢表型、代谢变化、代谢途径和发现生物标志物强大的分析工具。色谱-质谱联用技术整合了色谱的高效分离能力和质谱的强大分析功能，具有灵敏度高、选择性好、动态范围宽、信息丰富等优点，已成为代谢组学研究最常用的分析技术，能够在单次分析中获得数千种代谢物的信息，在血液、尿样和细胞等生物样品的代谢组学分析中占据重要地位。 然而，对于结构复杂和异质性高的生物组织或器官中的代谢物分析，色谱质谱联用分析方法具有局限性，原因
因此，从标准品匹配公共数据库结果来看，质谱（MS1,MS2）匹配度极高，而样本的二级质谱匹配会一定程度上受到基质的干扰，但从鉴定的角度看，适用性和匹配的程度仍较为可靠。 4.鹿明生物代谢组数据鉴定解析技巧—干货分享 基于鹿明生物代谢组平台的数据鉴定技巧分享： 技术平台背景：反相体系下的正负离子模式 DDA 模式分别采集，初始流动相比例为 95% 的高水相，数据采集时间为 16min； Tip 1：反相体系下，强极性代谢物的保留很弱，基本上在 1min 之前就会出峰，一些极性相对较小的代谢物会在中
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