c-Cbl pY774 Antibody, anti-hum

Detection of human phosphorylated c-Cbl pY774+ cellsClone REA118 recognizes the Y774-phosphorylated form of human c-Cbl, which is a member of Cbl family of proteins. Cbl proteins serve as the negative regulators of antigen receptor signaling and contain N-terminal tyrosine kinase-binding (TKB) domain, which mediates binding to specific phosphotyrosine motifs on activated protein tyosine kinases (PTKs), a Zn-coordinating RING finger domain that interacts with ubiquitin-conjugating enzymes (E2s), a proline-rich region and a C-terminal leucine zipper-like region. c-Cbl unlike the other cbl proteins contains only a short proline-rich region and no C-terminal leucine zipper-like region. Cbl proteins acts as E3 ubiquitin ligase and tranfer ubiquitin molecules to tag activated receptors, PTKS, and signaling molecules for degradation. | Additional information: Clone REA118 displays negligible binding to Fc receptors. |