NVP-BAG956,853910-02-8

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NVP-BAG956

CAS No. : 853910-02-8

MCE 国际站：NVP-BAG956

产品活性：NVP-BAG956 是一种 ATP 竞争性的 PI3K 抑制剂，抑制 PI3Kδ，PI3Kα，PI3Kγ 和 PI3Kβ，IC₅₀ 分别为 34, 56, 112 和 444 nM。

研究领域：PI3K/Akt/mTOR

作用靶点：PI3K

In Vitro: NVP-BAG956 also inhibits PDK1 with an IC₅₀ of 240/260 nM. NVP-BAG956 also inhibits VEGFR1 with an IC₅₀ of 2.56±0.56 μM. NVP-BAG956 blocks phosphorylation of PKB/Akt in A2058 cells with an IC₅₀ value of 67±25 nM. Inhibition of PKB/Akt phosphorylation correlated with loss of A2058 cell proliferation for NVP-BAG956 (IC₅₀=290±20 nM). In the presence of NVP-BAG956, A2058 cells are only able to exit G2-M and then remain in G1. The p27 ^Kip1 expression is clearly induced by NVP-BAG956 in A2058 cells but not in C32 cells.

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