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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
Rbx1 Antibody抗体
- 抗体英文名:
Rbx1 Antibody
- 应用范围:
IF, WB
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat
- 保质期:
6-12个月
- 抗原来源:
详询
- 目录编号:
orb412033
- 级别:
科研级
- 库存:
88
- 供应商:
biorbyt
- 标记物:
Unconjugated
- 克隆性:
Polyclonal
- 形态:
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
- 免疫原:
Recombinant fusion protein of human Rbx1
- 规格:
30 ul
别名:RNF75; ROC1; E3 ubiquitin-protein ligase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Rbx1; Regulator of cullins 1
免疫原:Recombinant fusion protein of human Rbx1
应用稀释比例:WB: 1:500-2000, IF/ICC: 1:50-200
纯化:The antibody was purified by immunogen affinity chromatography.
保存说明:Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Entrez:9978, 56438
UniProt ID:P62878, P62877
Note:For research use only.


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文献和实验modification of critical cysteine residues in Keap1 inhibits the enzymatic activity of the Keap1–Cul3–Rbx1 E3 ubiquitin ligase complex, resulting in decreased Nrf2 ubiquitination and degradation. As a consequence, free Nrf2 translocates into the nucleus
Molecular Analysis of the von Hippel-Lindau Disease Gene
. The VHL-elongin BC complex (VBC) also binds two other proteins—CUL2 and Rbx1—in a complex that has structural similarity to other E3 ubiquitin ligase complexes (6 ). Such complexes mediate the degradation of cell-cycle regulatory proteins.
同天两篇 Science,揭晓 miRNA 靶向降解机制,解了悬而未决近 30 年的谜题
现在 CYRANO 依赖的结合位点中,cullin-RING 泛素连接酶 (CRL) 的组件得分最高 (ZSWIM8、ELOB、ELOC、CUL3、RBX1 和 ARIH1),而 CRLs 是 E3 泛素连接酶的最大超家族。ZSWIM8 E3 泛素连接酶及其组件是 TDMD 必要条件与全基因组 CRISPR-Cas9 筛选结果一致,敲除 ZSWIM8 泛素连接酶的每个单独组件成分均可导致 EGFPmiR-7 报告基因在 CYRANO+/+ 细胞中被抑制,证实 ZSWIM8 E3 泛素连接酶及其组件是 TDMD
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