Cav1.3 Antibody (APC)抗体，orb148

产品描述：Mouse monoclonal to CaV1 (APC). 3. Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, CaV1. 3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. CaV1. 3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that CaV1. 3 is also found in the atria, and may figure prominently in atrial arrhythmias. CaV1. 3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells..

别名:Voltage-dependent L-type calcium channel subunit alpha-1D, Calcium channel, L type, alpha-1 polypeptide isoform 2, Voltage-gated calcium channel subunit alpha Cav1.3, CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2, alpha-1 polypeptide, CAC1D_HUMAN, Cacna1d, Calcium channel, Calcium channel L type alpha 1 polypeptide isoform 2, Calcium channel neuroendocrine/brain type alpha 1 subunit, Calcium channel voltage dependent L type alpha 1D subunit, isoform 2, L type, Voltage dependent L type calcium channel subunit alpha 1D, Voltage gated calcium channel alpha 1 subunit, Voltage gated calcium channel alpha subunit Cav1.3

免疫原：Fusion protein amino acids 859-875 of rat Cav1.3

克隆性:S48

分子量:250kDa

应用稀释比例：WB (1:1000), IHC (1:1000), ICC/IF (1:100)

应用注释：1 µg/ml of SMC-301 was sufficient for detection of Cav1.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

防腐剂:95.46mM Phosphate, 2.48mM MES and 2mM EDTA

纯化:Protein G Purified

保存说明:Conjugated antibodies should be stored according to the product label

NCBI:NP_058994.1

Entrez:29716

UniProt ID:P27732

Note:For research use only.