C6ORF173 Rabbit pAb, PE conjugated(bs-15230R-PE)-100ul产品图

C6ORF173 Rabbit pAb, PE conjug

ated(bs-15230R-PE)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-15230R-PE
  • 2025年12月01日
  • 产品信息以Bioss网站为准
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    • 规格:

      100ul

    产品编号bs-15230R-PE
    英文名称C6ORF173 Rabbit pAb, PE conjugated
    中文名称PE标记的6号染色体开放阅读框173抗体
    英文别名cancer upregulated gene 2; Cancer-up-regulated gene 2 protein; CENP-W; cenpw; CENPW_HUMAN; Centromere protein W; chromosome 6 open reading frame 173; CUG2; hypothetical protein LOC387103.
    产品应用ICC/IF=1:50-200, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human C6ORF173
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Oncoproteins/suppressors > Oncoproteins

    亚基Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting of histone H3, CENPT and CENPW. Interacts directly with CENPT. Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts with NPM1. Binds DNA.
    亚细胞定位Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.
    组织特异性Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types.
    相似性Belongs to the CENPW family.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.

     

    应用推荐稀释比例
    {ICC/IF}{1:50-200}
    {IF}{1:100-500}

     

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