- 询价
- R&D
- ZK-0102352
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- GABAA Receptor γ2 Subunit Polyclonal Antibody详细信息：
-
Description Polyclonal Antibody against GABAA Receptor γ2 Subunit Form Antiserum Host Rabbit Species Reactivity GABAA Receptor γ2 Subunit Polyclonal AntibodyRat. Bovine, human, mouse, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. Specificity Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α and β subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α subunits of the receptor. Lastly, phosphorylation of β subunits of the receptor has been shown to modulate GABAA-R function.
This antibody was developed against a peptide representing a sequence that is specific for the γ2 subunit of the receptor. It recognizes 45 - 47 k band in Western blots of rat brain membranes and the peptide antigen has no homology with any other GABAA-R or alpha or beta subunits.Uses GABAA Receptor γ2 Subunit Polyclonal AntibodyThis antibody is effective in immunoblotting; other applications not yet determined. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000*
- Dot blot: 1:1,000
Notes *Predicted MW = 45-47kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Long term storage should be at -80°C. This shelf-life of this product is approximately 1 year. References Kittler JT, McAinsh K, Moss SJ. Mechanisms of GABA A receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26:2251 - 268, 2002.
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate, GABAA receptor subtypes. In: International Review of Neurobiology (Bradley RJ, Harris RA, eds.), pp 95, San Diego: Academic Press, 1995.
Olsen RW, Tobin AJ. Molecular biology of GABAA receptors. FASEB 4:1469 - 1480, 1990.
Pritchett DB, Sontheimer H, Shivers BD, Yner S, Kettenman H, Schofield PR, Seeburg PH. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.Nature (London) 338:582-585, 1989.
Blair LAC, Levitan ES, Marshall J, Dionne VE, Barnard EA. Single subunits of the GABAA receptor form ion channels with properties of the native receptor. Science 242:577-579, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - GABAA Receptor γ2 Subunit Polyclonal Antibody
- zk-0979zk CD38(mouse, rat)CD38多肽（小鼠、大鼠）
zk-0980zk CD38(human)CD38抗原（人）
zk-1100zk CD36CD36（多肽）
zk-1520zk CD7CD7抗原
zk-1286zk CD40L(CD40 Ligand/TNFSF5/CD154)CD40L抗原
zk-0521zk CD44CD44抗原 (多肽抗原)
Y-0206 Argireline peptide 抗皱寡肽-1/六胜肽-3/阿基瑞林/乙酰六胜肽-3
Y-0207 GHRP-2 Acetate peptide(Growth hormone-releasing peptides 2)醋酸促生长激素释放肽2
Y-0208 GHRP-6 Acetate peptide(Growth hormone-releasing peptides 6)醋酸促生长激素释放肽6
Y-0209 Matrizkl Acetate五胜肽/美容肽—M肽
Y-0210 MT-II(Melanotan II Acetate)醋酸美拉诺坦II
Y-0211 Pentapeptide-3/Leuphasyl五胜肽
Y-0212 PT141(Bremelanotide PT-141)雌性激素肽
zk-0522zk CD45CD45(白细胞共同抗原)
zk-1539zk CD46/MCP(membrane cofactor protein)rat, mouse膜辅蛋白/内源性辅助因子活性蛋白抗原
zk-1113zk CD5CD5 多肽抗原
zk-0805zk CD56/NCAM1(Neural Cell Adhesion Molecule 1)神经细胞粘附分子1抗原
zk-1036zk CD62L (ELAM-1/L-Selectin )L选择素抗原
zk-1273zk E-SelectinE选择素抗原
zk-1479zk CD80/B7-1(human)人刺激分子B7-1蛋白抗原
zk-2211zk CD80/B7-1刺激分子B7-1蛋白抗原
zk-1470zk CD82/KAI1 peptide肿瘤转移抑制蛋白1抗原
zk-1035zk CD86/B7-2CD86抗原
zk-1341zk Cdc2/P34CDC2/CDK1(Cell division control protein 2)周期素依赖激酶1抗原
zk-1392zk Cdc34 peptide细胞周期调控因子34抗原
zk-0542zk CDK1 (Cyclin-Dependent Kinase 1)周期素依赖性激酶1抗原
zk-0559zk CDK5(Cyclin Dependent Kinase 5)周期素依赖性激酶5抗原
zk-0568zk CDK6 (Cyclin Dependent Kinase 6)周期素依赖性激酶6抗原
zk-0569zk CDK7/Cyclin H/MAT1周期素依赖性激酶7抗原
zk-0570zk CDK8(Cyclin Dependent Kinase 8)周期素依赖性激酶8抗原
zk-0538zk Cdkn1c/p57/Kip2 (Cyclindependent kinase inhibitor 1C)周期蛋白依赖激酶抑制因子1C抗原
zk-1093zk CGP-39/YKL-40(Chitinase-3-like protein 1 )软骨糖蛋白39（多肽）
zk-2080zk Cecropin抗菌肽/天蚕素（多肽）
zk-2048zk HER2 receptor(erbB-2 isoform 2)c-erbB-2受体抗原
zk-1085zk C-erbB-4/HER4/erbB-4 (epidermal growth factor receptor4)c-erbB-4癌基因抗原
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GABAA Receptor γ2 Subunit Polyclonal Antibody
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