- 询价
- R&D
- ZK-0101016
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- GABAA Receptor γ2 Subunit C-Terminus Loop Polyclonal Antibody保存于运输说明：
- Store at -20°C.
- 详细信息：
-
Description Polyclonal Antibody against GABAA Receptor γ2 C-Terminus Loop Form Affinity Purified Antibody in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. Host Rabbit Species Reactivity Bovine, Human, Mouse, Rat Specificity GABAA Receptor γ2 Subunit C-Terminus Loop Polyclonal AntibodyGamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α and β subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α subunits of the receptor. Lastly, phosphorylation of β subunits of the receptor has been shown to modulate GABAA-R function.
This antibody was raised against a fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABAA-R γ2-subunit. It was subsequently purified via affinity chromatography on column made with the γ2-cytoplasmic loop fusion protein. Specific for the 44 to 45k band of the GABAA-R γ2-subunit in rat brain membrane fractions.Uses This antibody is effective in immunoblotting; other applications not yet determined. Antibody dilutions and tissue load should be based on anticipated level of expression in the tissue to be tested. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000-2,000*
- Dot blot: 1:1,000-2,000
Notes GABAA Receptor γ2 Subunit C-Terminus Loop Polyclonal AntibodyPredicted MW = 44-45kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Long term storage should be at -80°C. This shelf-life of this product is approximately 1 year. References Kittler JT, McAinsh K, Moss SJ. Mechanisms of GABA A receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26:2251 - 268, 2002.
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate, GABAA receptor subtypes. In: International Review of Neurobiology (Bradley RJ, Harris RA, eds.), pp 95, San Diego: Academic Press, 1995.
Olsen RW, Tobin AJ. Molecular biology of GABAA receptors. FASEB 4:1469 - 1480, 1990.
Pritchett DB, Sontheimer H, Shivers BD, Yner S, Kettenman H, Schofield PR, Seeburg PH. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.Nature (London) 338:582-585, 1989.
Blair LAC, Levitan ES, Marshall J, Dionne VE, Barnard EA. Single subunits of the GABAA receptor form ion channels with properties of the native receptor. Science 242:577-579, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - GABAA Receptor γ2 Subunit C-Terminus Loop Polyclonal Antibody
- zk-0562zk CCR-2/5(CC chemokine receptor 2/5)CC趋化因子受体2/5抗原
zk-2450zk CCL1/TCA3/I-309嗜酸粒细胞趋化蛋白CCL1抗原
zk-1324zk CCL5/RANTES(regulated on activation normal T cell expressed and secreted)活化T细胞表达和分泌的调节因子抗原
zk-2475zk CCL4/MIP-1 Beta(Macrophage Inflammatory Protein 1 beta)巨噬细胞炎性蛋白1β抗原
zk-1268zk MIP3 Alpha/CCL20(Macrophage inflammatory ptotein 3 alpha)巨噬细胞炎性蛋白3α抗原
zk-2478zk CCL12/MCP-5(C-C motif chemokine 12)单核细胞趋化蛋白5抗原
zk-2479zk CCL14/HCC-1(C-C motif chemokine 14)嗜酸粒细胞趋化蛋白14抗原
zk-1761zk ABCD-1/CCL22嗜酸粒细胞趋化蛋白22抗原
zk-2454zk MIP-3 beta/ELC/CCL19(Macrophage Inflammatory Protein 3 Beta)巨噬细胞炎性蛋白19抗原
zk-1762zk CCL26(Eotaxin 3)嗜酸粒细胞趋化蛋白3抗原
zk-1169zk CCR-1(CC chemokine receptor 1)细胞表面趋化因子受体1抗原
zk-1167zk CCR-3(CC chemokine receptor 3)CC趋化因子受体3抗原
zk-1671zk CCR-2A(C-C Chemokine receptor 2A)细胞表面趋化因子受体2A抗原
zk-1168zk CCR-4(C-C chemokine receptor 4)细胞表面趋化因子受体4抗原
zk-1542zk CCR-6/CD196 peptide细胞表面趋化因子受体6抗原
zk-1628zk CXCR6(CXC-chemokine receptor 6) peptide细胞表面趋化因子受体6抗原
zk-1305zk CCR-7(CC chemokine receptor 7)CC趋化因子受体7（多肽）
zk-1502zk CXCL10/IP-10CXCL10趋化因子10/干扰素诱导蛋白10抗原
zk-0279zk VEGF(Vascular endothelial growth factor)血管内皮生长因子（多肽抗原）
zk-0527zk CD10/CALLA (Neutral Endopeptidase)CD10抗原
zk-0354zk ZCWCC1(Zinc finger CW-type coiled-coil domain protein 1)ZCWCC1抗原
zk-1309zk CD138/Syndecan-1多配体蛋白聚糖1抗原
zk-1618zk CD146/MCAM黑色素瘤细胞粘附分子CD146抗原
zk-1383zk ANPEN/CD13(Aminopeptidase N)氨肽酶N抗原
zk-1192zk CD14(cluster of differentiation antigen 14)CD14/内毒素受体抗原
zk-1297zk CD28CD28抗原
zk-1251zk CD166/ALCAM(activated leukocyte celladhesion molecule)活化白细胞粘附分子抗原
zk-1482zk CD177/NB1 peptide嗜中性粒细胞抗原CD177抗原
zk-0528zk CD24CD24抗原
zk-0512zk CD2AP (CD2-associated protein)白细胞分化抗原CD2AP
zk-1514zk CD33/Siglec-3(mouse ret)CD33抗原(大、小鼠）
zk-2038zk CD34CD34抗原（细胞表面的唾液粘蛋白）
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GABAA Receptor γ2 Subunit C-Terminus Loop Polyclonal Antibody
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