- 询价
- R&D
- ZK-0101538
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)详细信息：
-
Description Purified Monoclonal antibody against endoglin (CD105) clone SN6h Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone SN6h Form Protein G Purified Antibody (in PBS + 0.1% NaN3 + 1% BSA) Host Mouse Species Reactivity Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)Human IsoType IgG1 Specificity Endoglin (CD-105) is a type I membrane glycoprotein that is part of the TGF beta receptor complex.
Endoglin (CD 105) is expressed in vascular endothelial tissue as well as a variety of other tissues. Endoglin may also be involved in the cytoskeletal organization affecting cell morphology and migration. (2)
For formalin fixed paraffin embedded tissue sections, Covance recommends using the endoglin antibody with a polymer detection system such as Covance’s ACUITYAdvanced Polymer (SIG-32902).
Concentrated Format:
SIG-3770-1000 (1 mL)
Prediluted Format:
SIG-3770-26 (6 mL) is ready to use with polymer detection such as ACUITYAdvanced Biotin free Polymer Detection (SIG-32902).Uses This antibody is effective in immunohistochemisty on formalin fixed paraffin embedded sections. This antibody has been developed for use with a polymer detection kit such as ACUITYAdvanced Polymer Detection (SIG-32902). Suggested Working Dilution Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)The optimal working dilution should be determined for each specific assay condition. - IHC: 1:100 (concentrated format) with Biotin free, polymer detection systems such as ACUITYAdvanced Polymer Detecton (SIG-32902). This antibody is not recommended for use with biotin based, non-polymer kits.
Tissue Sections: Formalin-fixed, paraffin-embedded tissues
Pretreatment: Protease 8 for 10 minutes at room temperature.
Incubation: 60 minutes
Storage Store between 2-8°C. References (1) C Li, R Grady, BK Seon, SE Duff, S Abdalla, A Renehan, ST ODwyer, N Haboubi, S Kumar. Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 antibody in colorectal cancer patients correlate with poor prognosis. Br J Cancer 88:1424-1431, 2003.
(2) Sanz-Rodriguez, Francisco, et al. Endoglin regulates cytoskeletal organization through binding to ZRP-1 a member of the Lim family of proteins. J Biol Chem 279(31):32858-68, 2004.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - IHC: 1:100 (concentrated format) with Biotin free, polymer detection systems such as ACUITYAdvanced Polymer Detecton (SIG-32902). This antibody is not recommended for use with biotin based, non-polymer kits.
- Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)
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Endoglin (CD105) Clone SN6h Monoclonal Antibody, Purified (Signet)
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