- 询价
- R&D
- ZK-0002199
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- HIP-1 Monoclonal Antibody, Purified (SIGNET)详细信息：
-
Description Monoclonal Antibody against Huntingtin-Interacting Protein 1 (HIP-1)
(Formerly Signet Catalog Nos: 735-01, 735-16 L1 Predilute, 735-26 L2 Predilute)Intended Use **Analyte Specific Reagent**
Analytical and performance characteristics are not established.Clone 4B10.7 Form Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) Host Mouse Species Reactivity HIP-1 Monoclonal Antibody, Purified (SIGNET)Human IsoType IgG1 Specificity Clone 4B10 reacts with the Huntingtin-interacting protein 1 (HIP-1) (116-kDa) which is a cofactor in clathrin-mediated endocytosis. Clone 4B10 does not react with mouse HIP1. It was derived from a GST fusion construct that had GST cDNA fused to the HIP1 cDNA starting at its single EcoRI site (nt 1260).
Concentrated Format:
SIG-3735-1000 [1 mL]
Prediluted Formats:
SIG-3735-16 [L1 6 mL]
SIG-3735-26 [L2 6 mL]
Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.Uses This antibody is effective in immunohistochemistry (IHC). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - IHC: ≥1:40 (concentrated format) with Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues
Pretreatment: For optimal staining, the sections should be pretreated with an antigen unmasking solution such as Retreive-All 1 (SIG-31910).
Incubation: 60 minutes at room temperature
Storage HIP-1 Monoclonal Antibody, Purified (SIGNET)Store between 2-8°C. References Rao DS, Hyun TS, Kumar PD, Mizukami IF, Rubin MA, Lucas PC, Sanda MG, Ross TS. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J Clin Invest 110(3):351-60, 2002.
Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS. Huntingtin interacting protein 1 is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Mol Cell Biol 21(22):7796-806, 2001.
Mishra SK, Agostinelli NR, Brett TJ, Mizukami I, Ross TS, Traub LM. Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. J Biol Chem 276(49):46230-6, 2001.
Saint-Dic D, Chang SC, Taylor GS, Provot MM, Ross TS. Regulation of the Src homology 2-containing inositol 5-phosphatase SHIP1 in HIP1/PDGFbeta R-transformed cells. J Biol Chem 276(24):21192-8, 2001.
Ross TS, Gilliland DG. Transforming properties of the Huntingtin interacting protein 1/platelet-derived growth factor beta receptor fusion protein. J Biol Chem 274(32):22328-36, 1999.
Ross TS, Bernard OA, Berger R, Gilliland DG. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood 91(12):4419-26, 1998.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - IHC: ≥1:40 (concentrated format) with Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
- HIP-1 Monoclonal Antibody, Purified (SIGNET)
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HIP-1 Monoclonal Antibody, Purified (SIGNET)
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