- 询价
- R&D
- ZK-0101219
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Prion (3F4) Monoclonal Antibody, Purified (SIGNET) 详细信息：
-
Description Monoclonal Antibody against Prion Protein (3F4)
(Formerly Signet Catalog Nos: 9620-02, 9620-05, 9620-10)
Covance is the Exclusive Provider of this Antibody ProductIntended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 3F4 Form Purified Antibody (in PBS) Host Prion (3F4) Monoclonal Antibody, Purified (SIGNET)Mouse Species Reactivity Human, Hamster, Feline IsoType IgG2a [Ab] 2 mg/mL Specificity 3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturing). Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC) on unfixed tissues, immunoprecipitation (IP) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - WB: 1:10,000 - 1:100,000 (Refs 2, 4)
- IHC: 1:100 - 1:1,000 (Refs 2, 4)
Pretreatment: Epitope must be re-exposed in fixed tissue by pretreatment of tissue using one of the following procedures:
1. 70% Formic acid for 10-30 min at RT (Ref 1)
2. Hydrolytic autoclaving (Ref 2)
- IP: 1:10-1:100 (Ref 3, 4)
- ELISA: 1:100,000- 1:1,000,000 (Ref 2, 4)
Storage Prion (3F4) Monoclonal Antibody, Purified (SIGNET)Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). It is suggested that the total volume is aliquoted upon initial thaw. The antibody is best stored undiluted at -20°C to -70°C. References 1. Kondoh G, et al. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 11(2):160-66, 2005. (IHC)
2. Gilch S, et al. Recognition of lumenal prion proetin aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP. Traffic 5:300-313, 2004. (WB, IHC, ELISA)
3. Nishina K, et al. In vitro prion protein conversion in detergent solubilized membranes. Biochem 43:2613-2621, 2004. (IP)
4. Shiga Y, et al. Diffusion-weighted MRI abnormalities as an early marker for Creutzfeldt-Jakob disease. Neurol 63:443-449, 2004. (WB, IHC, IP, ELISA)
5. Zou W, et al. Antibody to DNA detects scrapie but not normal prion protein. PNAS 101(5):1380-1385, 2004.
6. Kitamoto T, et al. Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest 57:230-236, 1987.
7. Kascsak, et al. Mouse polyclonal and monoclonal antibody to scrapie associated fibril proteins. J Virol 61:3688-3693, 1987.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Prion (3F4) Monoclonal Antibody, Purified (SIGNET)
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Prion (3F4) Monoclonal Antibody, Purified (SIGNET)
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