- 询价
- R&D
- ZK-0101218
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Prion (3F4) Monoclonal Antibody, Biotin Labeled (SIGNET)详细信息：
-
Description Biotinylated Monoclonal Antibody against Prion Protein (3F4)
(Formerly Signet Catalog Nos: 9640-02, 9640-05, 9640-10)
Covance is the Exclusive Provider of this Antibody ProductIntended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 3F4 Form Biotin Labeled Antibody (in PBS) Host Mouse Species Reactivity Prion (3F4) Monoclonal Antibody, Biotin Labeled (SIGNET)Human, Hamster, Feline IsoType IgG2a [Ab] 1 mg/mL Specificity 3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denatured). Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC) on unfixed tissues, immunopurification (IP) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - WB: 1:10,000 - 1:100,000 (Refs 2, 4)
- IHC: 1:100 - 1:1,000 (Refs 2, 4)
Pretreatment: Epitope must be re-exposed in fixed tissue by pretreatment of tissue using one of the following procedures:
1. 70% Formic acid for 10-30 min at RT (Ref 1)
2. Hydrolytic autoclaving (Ref 2)
- IP: 1:10-1:100 (Ref 3, 4)
- ELISA: 1:100,000- 1:1,000,000 (Ref 2, 4)
Storage Prion (3F4) Monoclonal Antibody, Biotin Labeled (SIGNET)The antibody is best stored undiluted at -20°C to -70°C. Diluted solutions of the antibody must be stabilized by the addition of carrier protein (ie: add 2% bovine serum albumin). Even with carrier protein diluted antibody should only be stored for a short period of time. References 1. Kondoh G, et al. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 11(2):160-66, 2005. (IHC)
2. Gilch S, et al. Recognition of lumenal prion proetin aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP. Traffic 5:300-313, 2004.
3. Nishina K, et al. In vitro prion protein conversion in detergent solubilized membranes. Biochem 43:2613-2621, 2004.
4. Shiga Y, et al. Diffusion-weighted MRI abnormalities as an early marker for Creutzfeldt-Jakob disease. Neurol 63:443-449, 2004.
5. Zou W, et al. Antibody to DNA detects scrapie but not normal prion protein. PNAS 101(5):1380-1385, 2004.
6. Kitamoto T, et al. Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest 57:230-236, 1987.
7. Kascsak, et al. Mouse polyclonal and monoclonal antibody to scrapie associated fibril proteins. J Virol 61:3688-3693, 1987.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Prion (3F4) Monoclonal Antibody, Biotin Labeled (SIGNET)
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Prion (3F4) Monoclonal Antibody, Biotin Labeled (SIGNET)
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