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- 详细信息
- 文献和实验
- 技术资料
- 库存：
1000
- 英文名：
Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1)
- 保质期：
12个月
- 供应商：
上海再康
- 保存条件：
-20℃
| Organism species | Homo sapiens (Human) |
| Product No. | zk639Hu02 |
| Source | Prokaryotic expression |
| Host | E.coli |
| Purity | > 95% |
| UOM | 50ug |
| Predicted Molecular Mass | 20.6kDa |
| Concentration | n/a |
| Applications | SDS-PAGE; WB; ELISA; IP. |
| Endotoxin Level | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
MGHHHHHHSGS-LTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ WIN
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
白介素12受体β1(IL2Rβ1)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-β1
of the CI values in control cells during the time interval observed. However, this linear trend was significantly changed by TGF-β1 in less than 12 h after the treatment in a concentration-dependent manner (Fig. 1a). Concentrations of 1 and 10 ng/ml induced
练的是肌肉，为啥全身都受益？新研究揭示运动激活全身代谢的关键
的一种蛋白在肝脏中激活重要的细胞「自噬」过程，使肝脏的代谢功能更强。 根据论文，研究人员在实验小鼠运动前后对它们的血液进行了蛋白质组学分析，由此发现，运动诱导骨骼肌分泌一种叫做纤维粘连蛋白（FN1）的可溶性蛋白质。 而这些 FN1 蛋白随着血液循环到达肝脏后，通过肝细胞表面的一种受体整合素 α5β1 发出信号，在肝脏中激活「细胞自噬」过程，促进代谢适应。细胞自噬，简单来说就是细胞内的一种物质回收机制，降解和清除细胞内多余的蛋白质或受损的细胞器等。因此，运动在肝脏中激活细胞自噬也意味着这个代谢器官
【进展|热点】Nature：TGF-β并非Th17细胞分化的必要因素
09447.html?lang=en 内容简介： 传统的观点认为，TGF-β1对于Th17细胞的分化至关重要。但这篇文章却发现：TGF-β1并非Th17细胞分化的必需因素。因为TGF-β1信号通路缺失的小鼠小肠肠黏膜固有层内Th17细胞绝对数并没有减少。体外分化实验证实：在没有外源性TGF-β1以及采用中和抗体完全阻断内源性TGF-β1的活性的条件下，仅仅依靠IL-1β、IL-6和IL-23就可以诱导出Th17细胞。其中，IL-1β和IL-6可以诱导IL-23受体的表达，该作用可以被IL-23
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