- 询价
- R&D
- ZK-0002450
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- L1 (CD171) Monoclonal Antibody (SIGNET)详细信息：
-
Description Monoclonal Antibody against L1 (CD171)
(Formerly Signet Catalog No: 911-01, 911-16 L1 Predilute, 911-26 L2 Predilute)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 14.10 Form Purified Antibody (in PBS, pH 7.2 + 0.1% NaN3) Host Mouse IsoType L1 (CD171) Monoclonal Antibody (SIGNET)IgG1 Specificity Clone 14.10 recognizes L1, a 200-220 kDa transmembrane glycoprotein that functions as an adhesion molecule.
Concentrated Format:
SIG-3911-1000 [1 mL]
This format may be used with any detection system with final working dilutions optimized by the user. Recommended kits are USA HRP Multi-species Kit (SIG-32250) and ACUITYAdvanced Biotin Free Polymer Detection Kit (SIG-32902)
Prediluted Formats:
SIG-3911-16 [6 mL]
SIG-3911-26 [6 mL]
Both formats are ready-to-use with a biotin-based USA HRP (SIG-32250) or ACUITYAdvanced Biotin Free (SIG-32902) based detection systems.Uses This antibody is effective in immunohistochemistry (IHC). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - IHC: ≥1:40 for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections
Pretreatment: Not required
Incubation: 20 minutes at room temperature
Storage L1 (CD171) Monoclonal Antibody (SIGNET)Store between 2-8°C. References Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogela, M. Expression profile analysis in multiple human tumors Identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol **Article in Press** accepted 24 March, 2006
Kaifi JT, Heidtmann S, et al. Absence of L1 in pancreatic masses distinguishes adenocarcinomas from poorly differentiated neuroendocrine carcinomas. Anticancer Res 26(2A):1167-70, 2006.
Kaifi JT, et al. L1(CD171) is highly expressed in gastrointestinal stromal tumors.Mod Pathol 19(3):399-406, 2006.
Meier F, et al. The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer 119(3):549-55, 2006.
Stoeck A, et al. A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J 393:609-18, 2006.
Gutwein P, et al. Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. Clin Cancer Res 11(7):2492-501, 2005.
Fogel M, et al. L1 (CD171) as a novel biomarker for ovarian and endometrial carcimomas. Expert Rev Mol Diagn 4(4):455-62, 2004.
Deichmann M, et al. Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas). J. Cutan. Pathol. 30(6):363-8, 2003.
Fogel M, et al. L1 adhesion molecule (CD171) in development and progression of human malignant melanoma. Cancer Lett. 189(2):237-47, 2003.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - IHC: ≥1:40 for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
- L1 (CD171) Monoclonal Antibody (SIGNET)
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