粘蛋白-4抗体

粘蛋白-4抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

粘蛋白-4抗体产品介绍

肿瘤生物标志Tumor biomarkers
MUC4 (Mucin 4) is a high molecular weight transmembrane mucin that is overexpressed in many carcinomas and is a risk factor associated with a poor prognosis. MUC4 has been found to be a heterodimeric glycoprotein complex that consists of ASGP-1 (ascites sialoglycoprotein-1), an O-glycosylated mucin subunit, and ASGP-2, an N-glycosylated transmembrane subunit. ASGP-1 and ASGP-2 is a multifunctional glycoprotein complex. ASGP-1, through its O-glycosylation of the tandem repeat domain, provides anti-recognition and anti-adhesive properties to tumor cells. This property is involved in reducing the killing of tumor cells by natural killer cells and it is also important in high metastatic capacity of tumor cells. ASGP-2 has two epidermal growth factor-like domains. ASGP-2 appears to be able to bind and modulate ErbB2 receptor phosphorylation, which allows rapid growth of tumor cells. Sialomucin complex (SMC, rat homologue of human MUC4) expression is found in normal secretory epithelial tissues in the adult rat, where the protein has multiple regulatory mechanisms (Carraway, K.L. et al 1999). SMC is found in normal virgin mammary gland, elevated in the lactating gland, and further amplified in rat mammary adenocarcinoma. Transforming growth factor-beta (TGF-ß) inhibits SMC expression. Abnormal expression of MUC4/SMC is found in several human epithelial tumors such as, breast, lung, cervix, and pancreas carcinomas. Unregulated MUC4 may promote tumor metastasis, which suggests that it has an important role in human tumor biology. For example, several studies indicate that the cytoplasmic tail of the transmembrane mucin is involved in cell-signalling events such as Sos-ras pathway, beta-catenin, and ErbB2 signalling pathway.

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
mol wt:239/595kDa
Other Aliases:zk-8328R PP4R3B丝氨酸/苏氨酸蛋白磷酸酶3B抗体
zk-9547R PGGT1A蛋白香叶烯基转移酶1α抗体
zk-4895R PIRH2泛素连接酶抗体
zk-9371R PGBD3PGBD3蛋白抗体
zk-8340R PANK4泛酸激酶4抗体
zk-6443R PMCA1细胞膜钙ATP酶1抗体
zk-6450R PMCA4细胞膜钙ATP酶4抗体
zk-8201R PMCA4B细胞膜钙ATP酶4B抗体
zk-6499R PMCA细胞膜钙转运ATP酶抗体
zk-4710R SLCO2A1溶质载体蛋白家族21成员2抗体
zk-7872R PPHLN1脉周蛋白1抗体（胃癌抗原蛋白Ga50）
zk-9594R PINX-1端粒酶抑制因子PinX-1抗体
zk-6445R PRLR泌乳素受体抗体
zk-11622R PKD1L3多囊肾蛋白1样3抗体
zk-11623R PIRT磷酸肌醇相互作用蛋白抗体
zk-11739R Nucleoside phosphorylase嘌呤核苷磷酸化酶抗体
zk-8608R phospho-PKC Epsilon(Ser729)磷酸化蛋白激酶C/p-PKC ε抗体
zk-12035R Paralemmin 1细胞膜调控蛋白Paralemmin 1抗体
zk-3686R PHD2脯氨酸羟化酶2抗体
zk-2241R PSAP鞘脂激活蛋白原抗体
zk-3674R PBR外周苯二氮受体抗体
zk-7722R APRIN雄激素诱导增殖抑制蛋白抗体
zk-11993R Phosphoserine磷酸化丝氨酸抗体
zk-7711R PCNT中心粒周蛋白抗体
zkm-2006M PCNA(1C11)小鼠增殖细胞核抗原单克隆抗体
zk-5981R phospho-p107(Thr369) 磷酸化视网膜母细胞瘤样蛋白p107抗体
zk-9357R Proteasome 20S beta 3蛋白酶体PSMβ3抗体
zk-9358R Proteasome 20S beta 6蛋白酶体PSMβ6抗体
zk-9359R Proteasome 20S beta 7蛋白酶体PSMβ7抗体
zk-2567R PTP/PTPase/CD148蛋白酪氨酸磷酸酶CD148抗体
粘蛋白-4抗体