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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
该抗小鼠IFNAR1体内抗体, 克隆号MAR1-5A3的免疫原请参考该产品的说明书
- 保存条件:
当储存于2-8°C时,此抗体至少在2个月内是稳定的。对于长期储存,应分装原液并储存在-20°C或-80°C。避免反复冻融。
- 克隆性:
单克隆
- 适应物种:
Mouse
- 保质期:
当储存于2-8°C时,此抗体至少在2个月内是稳定的。对于长期储存,应分装原液并储存在-20°C或-80°C。避免反复冻融。
- 级别:
科研级别
- 库存:
999
- 供应商:
亚科因(Abbkine)
- 宿主:
Rat
- 应用范围:
in vivo IFNAR-1 blockade, Flow Cytometry
- 规格:
5mg
产品核心信息
- 中文全称:抗小鼠IFNAR1体内抗体, 克隆号MAR1-5A3
- 英文名称:InVivoPro Anti-Mouse IFNAR1 Antibody, Clone MAR1-5A3
- 产品货号:IV0123-5mg
- 供应商:InvivoCrown
- 产品类型:二抗
- 规格:5mg
背景与作用机制
IFNAR1(I型干扰素受体亚基1)与IFNAR2在几乎所有细胞类型中共表达,二者共同形成异二聚体I型IFN受体复合物,是I型干扰素(IFN-α/β)发挥生物学功能的关键分子基础。
I型IFN与该受体复合物结合后,可触发下游信号通路,诱导细胞产生多种核心应答:
- 抗病毒防御应答
- 抗菌免疫应答
- 抗肿瘤免疫应答
- 自身免疫应答调控
- 多种免疫细胞(如T细胞、B细胞、巨噬细胞等)的活化、增殖及分化调节
MAR1-5A3克隆抗体经实验验证,可在体内特异性阻断IFNAR1的功能,从而抑制I型IFN受体信号传导。
关键技术参数
- 应用场景:
- in vivo IFNAR-1 blockade(体内IFNAR1阻断实验)
- Flow Cytometry(流式细胞术分析)
- 来源宿主:Rat(大鼠)
- 物种反应性:Mouse(小鼠,仅针对小鼠来源IFNAR1)
- 免疫原信息:请参考产品说明书
储存与稳定性
- 短期储存:2-8°C避光保存,至少可稳定维持2个月
- 长期储存:建议分装为单次使用体积(避免反复冻融),储存于-20°C或-80°C环境中
- 注意事项:严格避免反复冻融循环,以免影响抗体活性
注意:以上信息可能随着产品优化升级等因素产生变动,具体信息请咨询亚科因公司。

Core Product Information
- Full Chinese Name: In Vivo Anti-Mouse IFNAR1 Antibody, Clone MAR1-5A3
- English Name: InVivoPro Anti-Mouse IFNAR1 Antibody, Clone MAR1-5A3
- Catalog Number: IV0123-5mg
- Supplier: InvivoCrown
- Product Type: Secondary Antibody
- Specification: 5mg
Background and Mechanism of Action
IFNAR1 (Type I Interferon Receptor Subunit 1) and IFNAR2 are co-expressed in almost all cell types, forming together the heterodimeric Type I IFN receptor complex, which is the key molecular basis for the biological functions of Type I interferons (IFN-α/β).
Upon binding to this receptor complex, Type I IFNs can trigger downstream signaling pathways, inducing various core cellular responses:
- Antiviral defense response
- Antibacterial immune response
- Antitumor immune response
- Regulation of autoimmune response
- Regulation of activation, proliferation, and differentiation of various immune cells (such as T cells, B cells, macrophages, etc.)
The MAR1-5A3 clone antibody has been experimentally verified to specifically block IFNAR1 function in vivo, thereby inhibiting Type I IFN receptor signaling.
Key Technical Parameters
- Application:
- in vivo IFNAR-1 blockade
- Flow Cytometry
- Host: Rat
- Species Reactivity: Mouse (specific to mouse IFNAR1)
- Immunogen Information: Please refer to the product manual
Storage and Stability
- Short-term Storage: Store at 2-8°C protected from light, stable for at least 2 months
- Long-term Storage: It is recommended to aliquot into single-use volumes (to avoid repeated freeze-thaw cycles) and store at -20°C or -80°C
- Precautions: Strictly avoid repeated freeze-thaw cycles to prevent affecting antibody activity
Note: The above information may change due to product optimization and upgrading. For specific information, please consult Yakeyin Company.
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