BioSIM 抗人 SOST/Sclerostin 抗体 (

BioSIM 抗人 SOST/Sclerostin 抗体 (罗莫索珠单抗生物类似药)

产品概述

BioSIM 抗人 SOST/Sclerostin 抗体 (罗莫索珠单抗生物类似药) 是一种高质量的科研级二抗，专为骨质疏松症及相关骨代谢研究而设计。该产品作为罗莫索珠单抗的生物类似药，保留了与治疗性抗体相同的可变区结构，确保了研究应用中的特异性和可靠性。

产品特点

• 高特异性：精准靶向骨细胞分泌的硬化蛋白(SOST)
• 研究适用性：专为非治疗性科研应用设计
• 一致性：与治疗性Romosozumab具有相同的可变区
• 人源化：Humanized来源宿主，降低免疫原性
• 多应用支持：适用于多种实验方法

技术参数

作用机制

罗莫索珠单抗是一种靶向骨细胞分泌硬化蛋白（SOST）的人源化IgG2κ单克隆抗体。SOST通过结合LRP4/5/6并抑制Wnt/β-catenin信号通路（成骨细胞的关键信号通路）来负向调控骨形成。该生物类似药可中和SOST，从而促进骨形成并抑制骨吸收，为研究骨合成代谢机制、Wnt信号通路以及SOST在骨生物学中的功能提供了有力工具。

应用领域

• ELISA：酶联免疫吸附测定
• FACS：流式细胞术
• Functional assay：功能分析
• Research in vivo：体内研究
• 核心研究领域：骨质疏松症

保存与处理

为确保产品活性和稳定性，请遵循以下保存建议：

• 避免反复冻融：防止抗体活性下降
• 短期保存（1-2周）：4°C
• 中期保存（最长12个月）：-20°C
• 长期保存：-80°C

免疫原信息请参考产品说明书。

订购信息

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human SOST/Sclerostin Antibody (Romosozumab Biosimilar)

Product Overview

BioSIM Anti-Human SOST/Sclerostin Antibody (Romosozumab Biosimilar) is a high-quality research-grade secondary antibody designed specifically for osteoporosis and related bone metabolism research. As a biosimilar of Romosozumab, this product retains the same variable region structure as the therapeutic antibody, ensuring specificity and reliability in research applications.

Product Features

• High Specificity: Precisely targets sclerostin (SOST) secreted by osteocytes
• Research Applicability: Designed specifically for non-therapeutic research applications
• Consistency: Same variable region as therapeutic Romosozumab
• Humanized: Humanized source host to reduce immunogenicity
• Multi-application Support: Suitable for various experimental methods

Technical Parameters

Mechanism of Action

Romosozumab is a humanized IgG2κ monoclonal antibody that targets sclerostin (SOST) secreted by osteocytes. SOST negatively regulates bone formation by binding to LRP4/5/6 and inhibiting the Wnt/β-catenin signaling pathway (a key signaling pathway for osteoblasts). This biosimilar can neutralize SOST, thereby promoting bone formation and inhibiting bone resorption, providing a powerful tool for studying anabolic bone mechanisms, Wnt signaling pathways, and the function of SOST in bone biology.

Application Areas

• ELISA: Enzyme-Linked Immunosorbent Assay
• FACS: Flow Cytometry
• Functional assay: Functional Analysis
• Research in vivo: In Vivo Research
• Core Research Areas: Osteoporosis

Storage and Handling

To ensure product activity and stability, please follow the storage recommendations below:

• Avoid repeated freeze-thaw cycles: Prevents decrease in antibody activity
• Short-term storage (1-2 weeks): 4°C
• Medium-term storage (up to 12 months): -20°C
• Long-term storage: -80°C

Please refer to the product manual for immunogenicity information.

Order Information

Note: The information above may change due to factors such as product optimization and upgrades. For specific information, please consult Yaokein Company.