BioSIM 抗人 SOST/Sclerostin 抗体 (

BioSIM 抗人 SOST/Sclerostin 抗体 (罗莫索珠单抗生物类似物)

产品货号：SIM0519-1mg

规格：1mg

供应商：InvivoCrown

CAS号：909395-70-6

产品概述

BioSIM抗人SOST/Sclerostin抗体是一种高特异性科研级试剂，作为罗莫索珠单抗的生物类似物，专为骨质疏松症及相关骨代谢疾病的研究而设计。该产品具有与治疗性Romosozumab相同的可变区结构，使其成为研究骨形成和吸收机制的理想工具。

产品特性

• 类型：人源化IgG2κ单克隆抗体
• 来源宿主：Humanized
• 反应性：Human
• 应用类型：ELISA, FACS, Functional assay, Research in vivo
• 研究领域：骨质疏松症、骨代谢、Wnt信号通路

科学背景

硬化蛋白(SOST)是由骨细胞分泌的重要调节因子，通过结合LRP4/5/6并抑制Wnt/β-catenin信号通路来负向调控骨形成。这一信号通路是成骨细胞功能的关键调节机制。BioSIM抗SOST抗体能够特异性中和SOST蛋白，从而促进骨形成并抑制骨吸收，为研究骨合成代谢机制提供了有力工具。

应用场景

• ELISA：用于检测和定量分析样本中SOST蛋白的表达水平
• FACS：流式细胞术分析，可用于研究SOST在细胞表面的表达和分布
• Functional assay：功能性分析，评估SOST中和对骨细胞功能的影响
• Research in vivo：体内研究，探索SOST在骨代谢和骨质疏松症中的作用机制

储存建议

• 避免反复冻融以保持抗体活性
• 短期使用（1-2周）：4°C保存
• 最长12个月储存：-20°C保存
• 长期储存：-80°C保存

注意事项

该产品仅供科研使用，不可用于临床诊断或治疗。免疫原性信息请参考产品说明书。在使用前，建议进行小规模实验以确定最佳工作浓度和实验条件。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human SOST/Sclerostin Antibody (Romosozumab Biosimilar)

Catalog Number: SIM0519-1mg

Specification: 1mg

Supplier: InvivoCrown

CAS Number: 909395-70-6

Product Overview

BioSIM anti-human SOST/Sclerostin antibody is a high-specificity research-grade reagent designed as a biosimilar of Romosozumab, specifically for the research of osteoporosis and related bone metabolic diseases. This product has the same variable region structure as therapeutic Romosozumab, making it an ideal tool for studying bone formation and resorption mechanisms.

Product Characteristics

• Type: Humanized IgG2κ monoclonal antibody
• Source Host: Humanized
• Reactivity: Human
• Application Type: ELISA, FACS, Functional assay, Research in vivo
• Research Areas: Osteoporosis, Bone metabolism, Wnt signaling pathway

Scientific Background

Sclerostin (SOST) is an important regulatory factor secreted by osteocytes that negatively regulates bone formation by binding to LRP4/5/6 and inhibiting the Wnt/β-catenin signaling pathway. This signaling pathway is a key regulatory mechanism for osteoblast function. BioSIM anti-SOST antibody can specifically neutralize SOST protein, thereby promoting bone formation and inhibiting bone absorption, providing a powerful tool for studying anabolic bone mechanisms.

Application Scenarios

• ELISA: Used for detection and quantitative analysis of SOST protein expression levels in samples
• FACS: Flow cytometry analysis, used to study the expression and distribution of SOST on the cell surface
• Functional assay: Functional analysis to evaluate the effects of SOST neutralization on osteocyte function
• Research in vivo: In vivo research to explore the mechanism of SOST in bone metabolism and osteoporosis

Storage Recommendations

• Avoid repeated freeze-thaw cycles to maintain antibody activity
• Short-term use (1-2 weeks): Store at 4°C
• Storage up to 12 months: Store at -20°C
• Long-term storage: Store at -80°C

Precautions

This product is for research use only and is not intended for clinical diagnosis or treatment. Please refer to the product manual for immunogenicity information. It is recommended to perform small-scale experiments before use to determine the optimal working concentration and experimental conditions.

Note: The above information may change due to factors such as product optimization and upgrading, please consult Yaokein Company for specific information.