BioSIM 抗人 IL-31Ra 抗体 (奈莫利珠单抗)，

BioSIM 抗人 IL-31Ra 抗体 (奈莫利珠单抗生物类似物)

产品概述

BioSIM anti-Human IL-31Ra Antibody是一种高特异性科研用生物类似物，精准模拟奈莫利珠单抗(Nemolizumab)的可变区结构，专为深入研究IL-31信号传导通路而设计。该抗体由InvivoCrown生产，产品货号SIM0510，规格为5mg，是探索神经免疫相互作用及止痒疗法开发的重要研究工具。

产品特性

• 产品类型：二抗
• CAS号：1476039-58-3
• 来源宿主：人源化(Humanized)
• 反应性：仅与人源(Human)IL-31RA结合
• 纯度：高纯度，适用于多种实验应用

科研应用价值

IL-31受体(IL-31RA)是介导IL-31生物学效应的关键分子，参与调控瘙痒、炎症等多种生理病理过程。该抗体通过特异性阻断IL-31与IL-31RA的结合，可有效中断特应性皮炎(AD)和瘙痒性神经性皮炎(PN)中的"瘙痒-抓挠"循环，为研究瘙痒机制及开发新型止痒疗法提供重要支持。

研究领域与应用

该抗体适用于多种研究场景：

• ELISA分析：定量检测样本中IL-31RA表达水平
• FACS流式细胞术：分析细胞表面IL-31RA表达与分布
• 功能实验：评估IL-31信号通路阻断效果
• 体内研究：探索IL-31在动物模型中的生物学功能

保存与稳定性

为确保抗体活性与稳定性，请遵循以下保存条件：

• 避免反复冻融，以维持抗体最佳活性
• 短期使用(1-2周)：4°C保存
• 中期保存(最长12个月)：-20°C保存
• 长期保存：-80°C保存

产品优势

作为奈莫利珠单抗的生物类似物，该抗体具有与原研药物相同的可变区结构，确保了研究结果的可靠性与可重复性。其高特异性使其成为研究IL-31信号传导、探索特应性皮炎发病机制以及开发新型止痒疗法的理想选择。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human IL-31Ra Antibody (Biosimilar of Nemolizumab)

Product Overview

BioSIM anti-Human IL-31Ra Antibody is a high-specificity research-grade biosimilar that precisely mimics the variable region structure of Nemolizumab, specially designed for in-depth research of the IL-31 signaling pathway. Produced by InvivoCrown with product number SIM0510 and specification of 5mg, this antibody serves as an important research tool for exploring neuroimmune interactions and developing antipruritic therapies.

Product Features

• Product Type: Secondary Antibody
• CAS Number: 1476039-58-3
• Source Host: Humanized
• Reactivity: Binds only to Human IL-31RA
• Purity: High purity, suitable for various experimental applications

Research Application Value

IL-31 receptor (IL-31RA) is a key molecule mediating the biological effects of IL-31, involved in regulating various physiological and pathological processes including pruritus and inflammation. This antibody specifically blocks the binding of IL-31 to IL-31RA, effectively interrupting the "itch-scratch" cycle in atopic dermatitis (AD) and pruritic neurodermatitis (PN), providing important support for studying pruritus mechanisms and developing novel antipruritic therapies.

Research Fields and Applications

This antibody is suitable for various research scenarios:

• ELISA Analysis: Quantitative detection of IL-31RA expression levels in samples
• FACS Flow Cytometry: Analysis of cell surface IL-31RA expression and distribution
• Functional Experiments: Evaluation of IL-31 signaling pathway blockade effects
• In Vivo Studies: Exploration of IL-31 biological functions in animal models

Storage and Stability

To ensure antibody activity and stability, please follow the following storage conditions:

• Avoid repeated freeze-thaw cycles to maintain optimal antibody activity
• Short-term use (1-2 weeks): Store at 4°C
• Medium-term storage (up to 12 months): Store at -20°C
• Long-term storage: Store at -80°C

Product Advantages

As a biosimilar of Nemolizumab, this antibody has the same variable region structure as the original drug, ensuring the reliability and reproducibility of research results. Its high specificity makes it an ideal choice for studying IL-31 signaling, exploring the pathogenesis of atopic dermatitis, and developing novel antipruritic therapies.

Note: The information above may change due to factors such as product optimization and upgrades. For specific information, please consult Yacoin Company.