BioSIM 抗人 IL-31Ra 抗体 (奈莫利珠单抗)，

BioSIM 抗人 IL-31Ra 抗体 (奈莫利珠单抗生物类似物)

产品基本信息

英文名称：BioSIM anti-Human IL-31Ra Antibody (Nemolizumab Biosimilar), Research Grade
中文名称：BioSIM 抗人 IL-31Ra 抗体 (奈莫利珠单抗)，生物类似药，科研用途 [ CAS: 1476039-58-3 ]
产品类型：二抗
供应商：InvivoCrown
产品货号：SIM0510-1mg
产品规格：1mg

产品简介

BioSIM 抗人 IL-31Ra 抗体是一种高特异性科研级试剂，作为奈莫利珠单抗(Nemolizumab)的生物类似物，具有与治疗性抗体相同的可变区结构。该抗体靶向人IL-31受体α(IL-31Ra)，是研究IL-31信号通路及其在瘙痒和炎症反应中作用的理想工具。

产品背景与应用价值

IL-31是由活化的T细胞产生的细胞因子，通过与IL-31Ra结合，参与多种生理和病理过程，尤其是介导瘙痒和炎症反应。奈莫利珠单抗通过阻断IL-31与IL-31Ra的结合，能够有效中断特应性皮炎(AD)和慢性瘙痒症(PN)中的瘙痒-抓挠循环，为相关疾病的治疗提供了新的思路。

研究领域

• 瘙痒机制研究
• 特应性皮炎(AD)病理生理学
• 神经免疫相互作用
• 止痒疗法开发
• IL-31信号传导通路研究

技术参数

• 免疫原性：详情请参考产品说明书
• 来源宿主：人源化(Humanized)
• 反应性：仅针对人源样本(Human)
• 纯度：根据供应商提供的技术规格
• 浓度：根据产品规格确定

应用方法

• ELISA (酶联免疫吸附测定)
• FACS (流式细胞术)
• Functional assay (功能实验)
• Research in vivo (体内研究)

储存条件

重要提示：为保持抗体活性，请避免反复冻融。

• 短期储存(1-2周)：4°C
• 中期储存(最长12个月)：-20°C
• 长期储存：-80°C

订购信息

产品货号：SIM0510-1mg
包装规格：1mg
供应商：InvivoCrown

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human IL-31Ra Antibody (Nemolizumab Biosimilar)

Product Basic Information

English Name: BioSIM anti-Human IL-31Ra Antibody (Nemolizumab Biosimilar), Research Grade
Chinese Name: BioSIM 抗人 IL-31Ra 抗体 (奈莫利珠单抗)，生物类似药，科研用途 [ CAS: 1476039-58-3 ]
Product Type: Secondary Antibody
Supplier: InvivoCrown
Catalog Number: SIM0510-1mg
Specification: 1mg

Product Introduction

BioSIM anti-Human IL-31Ra Antibody is a highly specific research-grade reagent that serves as a biosimilar of Nemolizumab, featuring identical variable region structure to the therapeutic antibody. This antibody targets human IL-31 receptor alpha (IL-31Ra) and is an ideal tool for studying the IL-31 signaling pathway and its role in pruritus and inflammatory responses.

Product Background and Application Value

IL-31 is a cytokine produced by activated T cells that, upon binding to IL-31Ra, participates in various physiological and pathological processes, particularly mediating pruritus and inflammatory responses. Nemolizumab effectively interrupts the itch-scratch cycle in atopic dermatitis (AD) and prurigo nodularis (PN) by blocking the binding of IL-31 to IL-31Ra, providing new approaches for treating related diseases.

Research Areas

• Pruritus mechanism research
• Atopic dermatitis (AD) pathophysiology
• Neuroimmune interactions
• Anti-pruritic therapy development
• IL-31 signaling pathway research

Technical Parameters

• Immunogenicity: Please refer to the product manual for details
• Source Host: Humanized
• Reactivity: Human only
• Purity: According to the technical specifications provided by the supplier
• Concentration: Determined according to product specifications

Application Methods

• ELISA (Enzyme-Linked Immunosorbent Assay)
• FACS (Flow Cytometry)
• Functional assay
• Research in vivo

Storage Conditions

Important Note: To maintain antibody activity, please avoid repeated freeze-thaw cycles.

• Short-term storage (1-2 weeks): 4°C
• Medium-term storage (up to 12 months): -20°C
• Long-term storage: -80°C

Ordering Information

Catalog Number: SIM0510-1mg
Packaging Size: 1mg
Supplier: InvivoCrown

Note: The above information may change due to product optimization and upgrading, etc. Please consult Yaokeen Company for specific information.