BioSIM 抗人 GPRC5D x CD3 抗体 (塔奎妥

BioSIM 抗人 GPRC5D x CD3 双特异性抗体 (塔奎妥单抗生物类似药)

产品概述

BioSIM anti-Human GPRC5D x CD3 Bispecific Antibody 是一种高纯度科研级双特异性抗体，作为治疗性Talquetamab的生物类似药，专为多发性骨髓瘤研究而设计。该抗体具有与原研药物相同的可变区结构，确保研究结果的可靠性和可重复性。

产品特性

• 产品类型：双特异性抗体 (BiTE结构)
• 靶向特性：同时靶向GPRC5D和CD3ε
• 来源宿主：人源化 (Humanized)
• 反应性：仅与人源蛋白反应
• 货号规格：SIM0392-1mg (1mg规格)
• CAS号：2226212-40-2

作用机制

该抗体通过桥接T细胞表面的CD3ε受体和多发性骨髓瘤细胞表面高表达的GPRC5D抗原，形成免疫突触。这种特异性结合能够激活T细胞，促进穿孔素和颗粒酶的释放，进而诱导GPRC5D阳性肿瘤细胞的凋亡，为多发性骨髓瘤的免疫治疗研究提供有力工具。

研究领域与应用

BioSIM 抗人 GPRC5D x CD3 抗体适用于多种研究场景：

• 免疫学研究：T细胞活化机制研究
• 肿瘤学研究：多发性骨髓瘤细胞靶向治疗研究
• 应用方法：
  • ELISA - 定量检测与分析
  • FACS - 流式细胞术分析
  • Functional assay - 功能性实验
  • Research in vivo - 体内研究应用

储存与处理建议

为确保抗体活性和稳定性，请遵循以下储存指南：

• 避免反复冻融，以防止蛋白变性
• 短期储存：1-2周内，请于4°C保存
• 中期储存：最长12个月，请于-20°C保存
• 长期储存：超过12个月，请于-80°C保存
• 使用前请平衡至室温，并轻柔混匀

注意事项

本产品仅限科研用途，不可用于临床诊断或治疗。关于免疫原性信息，请参考产品说明书。建议在实验设置中包含适当的阳性对照和阴性对照，以确保实验结果的可靠性。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human GPRC5D x CD3 Bispecific Antibody (Talquetamab Biosimilar)

Product Overview

BioSIM anti-Human GPRC5D x CD3 Bispecific Antibody is a high-purity research-grade bispecific antibody designed as a therapeutic Talquetamab biosimilar specifically for multiple myeloma research. This antibody has the same variable region structure as the original drug, ensuring the reliability and reproducibility of research results.

Product Features

• Product Type: Bispecific Antibody (BiTE structure)
• Target Specificity: Targets both GPRC5D and CD3ε simultaneously
• Source Host: Humanized
• Reactivity: Reacts only with human proteins
• Catalog Number: SIM0392-1mg (1mg specification)
• CAS Number: 2226212-40-2

Mechanism of Action

This antibody bridges the CD3ε receptor on the surface of T cells and the highly expressed GPRC5D antigen on the surface of multiple myeloma cells, forming an immunological synapse. This specific binding activates T cells, promotes the release of perforin and granzymes, and subsequently induces apoptosis of GPRC5D-positive tumor cells, providing a powerful tool for immunotherapy research in multiple myeloma.

Research Areas and Applications

BioSIM Anti-Human GPRC5D x CD3 Antibody is suitable for various research scenarios:

• Immunology Research: T cell activation mechanism studies
• Cancer Research: Targeted therapy research for multiple myeloma cells
• Application Methods:
  • ELISA - Quantitative detection and analysis
  • FACS - Flow cytometry analysis
  • Functional assay - Functional experiments
  • Research in vivo - In vivo research applications

Storage and Handling Recommendations

To ensure antibody activity and stability, please follow the storage guidelines below:

• Avoid repeated freeze-thaw cycles to prevent protein denaturation
• Short-term Storage: Within 1-2 weeks, store at 4°C
• Medium-term Storage: Up to 12 months, store at -20°C
• Long-term Storage: For more than 12 months, store at -80°C
• Before use, equilibrate to room temperature and gently mix

Precautions

This product is for research use only and is not intended for clinical diagnosis or treatment. For immunogenicity information, please refer to the product manual. It is recommended to include appropriate positive and negative controls in the experimental setup to ensure the reliability of experimental results.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yikouin Company.