BioSIM 抗人 VEGFR2 抗体 (雷莫芦单抗)，生物

BioSIM 抗人 VEGFR2 抗体 (雷莫芦单抗生物类似药) - 科研级

产品核心信息

• 英文名称：BioSIM anti-Human VEGFR2 Antibody (Ramucirumab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 VEGFR2 抗体 (雷莫芦单抗)，生物类似药，科研用途
• CAS号：947687-13-0
• 产品类型：二抗
• 供应商：InvivoCrown
• 货号：SIM0050-5mg
• 规格：5mg

产品背景与分子特性

该产品为非治疗性雷莫芦单抗生物类似药，其可变区序列与临床治疗用雷莫芦单抗完全一致，专为科研场景优化设计，可特异性结合人VEGFR-2（CD309/KDR/Flk-1，酪氨酸蛋白激酶家族关键成员）。

VEGFR-2的核心生物学功能：

• 与VEGF家族配体（VEGF-A/C/D）特异性结合，调控血管生成、内皮细胞通透性及存活；
• 成人组织中高表达于心脏、肺、肾、脑及骨骼肌的内皮细胞，是血管稳态的核心调控分子；
• 通过阻断VEGF配体结合，抑制VEGF介导的肿瘤血管生成，是实体瘤研究的经典靶点。

适配研究领域：晚期实体瘤、胃癌、非小细胞肺癌（NSCLC）等血管生成依赖型肿瘤研究。

应用场景与兼容性

该抗体经初步验证可支持以下科研应用（具体实验参数请参考产品说明书）：

• ELISA：适用于人VEGFR-2蛋白的定量检测与浓度分析；
• FACS：可用于流式细胞术分选/分析表达VEGFR-2的内皮细胞亚群；
• Functional assay：用于评估VEGFR-2信号通路活性及抗体的阻断效果；
• Research in vivo：可用于动物模型中的体内血管生成相关机制研究。

来源宿主：Human（人源化抗体，显著降低体内免疫原性风险）；

反应性：仅针对Human（人）VEGFR-2（无交叉反应数据需以说明书为准）。

储存与稳定性建议

为维持抗体活性与稳定性，需严格遵循以下储存条件：

• 短期使用（1-2周）：4°C避光保存（避免反复冻融）；
• 中期储存（≤12个月）：-20°C避光保存，建议分装为单次使用量；
• 长期储存（＞12个月）：-80°C避光保存，分装后可延长稳定储存周期（具体有效期以产品标签为准）。

注意事项：反复冻融会导致抗体聚集或活性下降，每次使用前请缓慢解冻并轻轻混匀，避免剧烈震荡。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human VEGFR2 Antibody (Ramucirumab Biosimilar) - Research Grade

Product Core Information

• English Name: BioSIM anti-Human VEGFR2 Antibody (Ramucirumab Biosimilar), Research Grade
• Chinese Name: BioSIM Anti-Human VEGFR2 Antibody (Ramucirumab), Biosimilar, Research Use
• CAS Number: 947687-13-0
• Product Type: Secondary Antibody
• Supplier: InvivoCrown
• Catalog Number: SIM0050-5mg
• Specification: 5mg

Product Background and Molecular Characteristics

This product is a non-therapeutic Ramucirumab biosimilar with variable region sequences identical to the clinically used Ramucirumab. It is specifically optimized for research applications and can specifically bind to human VEGFR-2 (CD309/KDR/Flk-1, a key member of the tyrosine protein kinase family).

Core Biological Functions of VEGFR-2:

• Specifically binds to VEGF family ligands (VEGF-A/C/D) to regulate angiogenesis, endothelial cell permeability, and survival;
• Highly expressed in endothelial cells of heart, lung, kidney, brain, and skeletal muscle in adult tissues, serving as a core regulatory molecule for vascular homeostasis;
• Inhibits VEGF-mediated tumor angiogenesis by blocking VEGF ligand binding, making it a classical target for solid tumor research.

Suitable Research Fields: Research on angiogenesis-dependent tumors such as advanced solid tumors, gastric cancer, non-small cell lung cancer (NSCLC), etc.

Applications and Compatibility

This antibody has been preliminarily validated to support the following research applications (for specific experimental parameters, please refer to the product manual):

• ELISA: Suitable for quantitative detection and concentration analysis of human VEGFR-2 protein;
• FACS: Can be used for flow cytometry sorting/analysis of endothelial cell subpopulations expressing VEGFR-2;
• Functional assay: Used to evaluate VEGFR-2 signaling pathway activity and antibody blocking effects;
• Research in vivo: Can be used for in vivo angiogenesis-related mechanism studies in animal models.

Source Host: Human (Humanized antibody, significantly reducing in vivo immunogenicity risks);

Reactivity: Specific to Human VEGFR-2 only (cross-reactivity data should be confirmed in the product manual).

Storage and Stability Recommendations

To maintain antibody activity and stability, the following storage conditions must be strictly followed:

• Short-term use (1-2 weeks): Store at 4°C protected from light (avoid repeated freeze-thaw cycles);
• Medium-term storage (≤12 months): Store at -20°C protected from light, aliquoting into single-use quantities is recommended;
• Long-term storage (>12 months): Store at -80°C protected from light, aliquoting can extend the stable storage period (refer to product label for specific expiration date).

Precautions: Repeated freeze-thaw cycles may cause antibody aggregation or decreased activity. Before each use, please thaw slowly and mix gently, avoiding vigorous shaking.

Note: The above information may change due to product optimization and upgrades. For specific information, please contact InvivoCrown.