BioSIM 抗人 IL-1b 抗体 (卡那单抗)，生物类似

BioSIM 抗人 IL-1b 抗体 (卡那单抗生物类似药)，科研用途

产品概述

BioSIM anti-Human IL-1b Antibody (Canakinumab Biosimilar) 是一种高亲和力的人源化IgG1单克隆抗体，专为科研应用设计。作为卡那单抗的生物类似药，该抗体与治疗性卡那单抗具有相同的可变区序列，能够特异性靶向并结合人白细胞介素-1β(IL-1β)，在炎症相关疾病研究中具有重要价值。

产品特点

• 高特异性：仅识别并结合人IL-1β，不与IL-1α或IL-1ra交叉反应
• 中和活性：通过阻断IL-1β与其受体的相互作用，有效中和IL-1β的生物活性
• 科研级品质：专为科研应用优化，确保实验结果的可靠性和重复性
• 多种应用兼容：适用于ELISA、流式细胞术(FACS)、功能性实验和体内研究等多种实验平台

技术参数

应用领域

该抗体适用于多种炎症相关疾病的研究，包括：

• 痛风发病机制研究
• 慢性婴儿神经、皮肤及关节综合征(CINCA)相关研究
• 全身型幼年特发性关节炎(SJIA)的病理机制探索
• IL-1β介导的炎症信号通路研究
• 抗炎药物筛选和评估

实验应用

• ELISA：用于检测样本中人IL-1β的浓度
• FACS：用于流式细胞术分析IL-1β表达
• 功能性实验：评估IL-1β的生物活性和信号传导
• 体内研究：动物模型中IL-1β相关疾病机制研究

保存与稳定性

为确保抗体活性和稳定性，请遵循以下储存条件：

• 避免反复冻融，以防抗体活性降低
• 短期使用（1-2周）：储存于4°C
• 中期储存（最长12个月）：储存于-20°C
• 长期储存：推荐储存于-80°C
• 建议分装保存，减少反复冻融次数

订购信息

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human IL-1b Antibody (Canakinumab Biosimilar), Research Use

Product Overview

BioSIM anti-Human IL-1b Antibody (Canakinumab Biosimilar) is a high-affinity humanized IgG1 monoclonal antibody designed specifically for research applications. As a biosimilar to canakinumab, this antibody shares the same variable region sequence as therapeutic canakinumab and specifically targets and binds to human interleukin-1 beta (IL-1β), making it valuable for research on inflammation-related diseases.

Product Features

• High Specificity: Recognizes and binds only to human IL-1β, with no cross-reactivity to IL-1α or IL-1ra
• Neutralizing Activity: Effectively neutralizes the biological activity of IL-1β by blocking its interaction with its receptor
• Research-Grade Quality: Optimized for research applications to ensure reliable and reproducible experimental results
• Multi-Application Compatibility: Suitable for various experimental platforms including ELISA, flow cytometry (FACS), functional assays, and in vivo studies

Technical Parameters

Application Fields

This antibody is suitable for research on various inflammation-related diseases, including:

• Pathogenesis research of gout
• Studies related to Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome
• Exploration of pathological mechanisms in Systemic Juvenile Idiopathic Arthritis (SJIA)
• Research on IL-1β-mediated inflammatory signaling pathways
• Screening and evaluation of anti-inflammatory drugs

Experimental Applications

• ELISA: For detecting the concentration of human IL-1β in samples
• FACS: For flow cytometry analysis of IL-1β expression
• Functional Assays: To evaluate the biological activity and signal transduction of IL-1β
• In Vivo Studies: Research on IL-1β-related disease mechanisms in animal models

Storage and Stability

To ensure antibody activity and stability, please follow the following storage conditions:

• Avoid repeated freeze-thaw cycles to prevent reduced antibody activity
• Short-term use (1-2 weeks): Store at 4°C
• Medium-term storage (up to 12 months): Store at -20°C
• Long-term storage: Recommended storage at -80°C
• It is recommended to aliquot for storage to reduce the number of freeze-thaw cycles

Ordering Information

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult InvivoCrown.