BioSIM 抗人 IL-1b 抗体 (卡那单抗)，生物类似

BioSIM 抗人 IL-1β 抗体 (卡那单抗生物类似药)

产品概述

BioSIM 抗人 IL-1β 抗体 (卡那单抗生物类似药) 是一种高特异性的科研级抗体，与人白细胞介素-1β (IL-1β) 具有高亲和力结合能力。作为治疗性抗体卡那单抗的生物类似药，该产品保留了原始抗体的可变区结构，使其成为研究IL-1β信号通路及相关疾病模型的理想工具。

产品信息

• 产品名称：BioSIM anti-Human IL-1b Antibody (Canakinumab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 IL-1b 抗体 (卡那单抗)，生物类似药，科研用途
• CAS号：914613-48-2
• 产品类型：二抗
• 供应商：InvivoCrown
• 产品货号：SIM0362-1mg
• 产品规格：1mg
• 来源宿主：Human
• 反应性：Human

产品特性

该抗体为全人源 IgG1 单克隆抗体，能够特异性识别并结合人 IL-1β，一种由单核细胞产生的17 kDa促炎细胞因子。IL-1β在介导炎症反应、细胞增殖和免疫调节中发挥关键作用。该抗体通过阻断IL-1β与其受体相互作用来中和其生物活性，但不与IL-1α或IL-1ra结合，确保了研究的特异性和准确性。

研究领域与应用

该抗体广泛应用于多种IL-1β相关疾病的研究：

• 炎症性疾病研究：痛风、类风湿性关节炎
• 自身免疫性疾病：全身型幼年特发性关节炎
• 神经系统疾病：慢性婴儿神经、皮肤及关节综合征
• 其他炎症相关疾病模型研究

实验应用

BioSIM 抗人 IL-1β 抗体适用于多种实验方法：

• ELISA：用于IL-1β的定量检测
• FACS：流式细胞术检测细胞表面IL-1β表达
• Functional assay：功能性实验评估IL-1β活性
• Research in vivo：体内研究IL-1β相关疾病模型

储存建议

为确保抗体活性和稳定性，请遵循以下储存条件：

• 避免反复冻融，以保持抗体活性
• 短期使用（1-2周）：4°C保存
• 中期储存（最长12个月）：-20°C保存
• 长期储存：-80°C保存

免疫原性

该产品的免疫原性信息请参考产品说明书。建议在使用前仔细阅读相关资料，以确定其在特定实验体系中的适用性。

技术支持

InvivoCrown 提供专业的技术支持服务，帮助研究人员优化实验方案，解决实验中可能遇到的问题。如需更多技术信息或应用指导，请联系我们的技术支持团队。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human IL-1β Antibody (Canakinumab Biosimilar)

Product Overview

BioSIM anti-Human IL-1β Antibody (Canakinumab Biosimilar) is a highly specific research-grade antibody with high affinity binding capability to human interleukin-1β (IL-1β). As a biosimilar of the therapeutic antibody Canakinumab, this product retains the variable region structure of the original antibody, making it an ideal tool for studying IL-1β signaling pathways and related disease models.

Product Information

• Product Name:BioSIM anti-Human IL-1b Antibody (Canakinumab Biosimilar), Research Grade
• Chinese Name:BioSIM anti-Human IL-1b Antibody (Canakinumab), Biosimilar, Research Use
• CAS Number:914613-48-2
• Product Type:Secondary Antibody
• Supplier:InvivoCrown
• Catalog Number:SIM0362-1mg
• Specification:1mg
• Host Species:Human
• Reactivity:Human

Product Characteristics

This antibody is a fully human IgG1 monoclonal antibody that specifically recognizes and binds to human IL-1β, a 17 kDa pro-inflammatory cytokine produced by monocytes. IL-1β plays a crucial role in mediating inflammatory responses, cell proliferation, and immune regulation. The antibody neutralizes its biological activity by blocking the interaction of IL-1β with its receptor, but does not bind to IL-1α or IL-1ra, ensuring specificity and accuracy in research.

Research Areas and Applications

This antibody is widely used in the study of various IL-1β-related diseases:

• Inflammatory Disease Research:Gout, Rheumatoid Arthritis
• Autoimmune Diseases:Systemic Juvenile Idiopathic Arthritis
• Neurological Disorders:Chronic Infantile Neurological Cutaneous and Articular Syndrome
• Other Inflammation-Related Disease Model Research

Experimental Applications

BioSIM anti-Human IL-1β Antibody is suitable for various experimental methods:

• ELISA:For quantitative detection of IL-1β
• FACS:Flow cytometry for detecting cell surface IL-1β expression
• Functional assay:Functional experiments to evaluate IL-1β activity
• In vivo research:In vivo study of IL-1β-related disease models

Storage Recommendations

To ensure antibody activity and stability, please follow the following storage conditions:

• Avoid repeated freeze-thaw cycles to maintain antibody activity
• Short-term use (1-2 weeks): Store at 4°C
• Medium-term storage (up to 12 months): Store at -20°C
• Long-term storage: Store at -80°C

Immunogenicity

Please refer to the product manual for immunogenicity information of this product. It is recommended to carefully read the relevant materials before use to determine its suitability in specific experimental systems.

Technical Support

InvivoCrown provides professional technical support services to help researchers optimize experimental protocols and solve problems that may be encountered during experiments. For more technical information or application guidance, please contact our technical support team.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yaokein Company.