BioSIM 抗人 CD20 抗体 (奥法木单抗 / 奥法妥

BioSIM 抗人 CD20 抗体 (奥法木单抗 / 奥法妥木单抗)，生物类似药，科研用途

产品核心参数

• 英文名称：BioSIM anti-Human CD20 Antibody (Ofatumumab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 CD20 抗体 (奥法木单抗 / 奥法妥木单抗)，生物类似药，科研用途
• CAS号：679818-59-8
• 供应商：InvivoCrown
• 产品货号：SIM0067-5mg
• 产品规格：5mg
• 产品类型：二抗
• 来源宿主：Human（全人源）
• 反应性：Human（仅识别人源CD20抗原）

产品背景与科学特性

本产品为奥法木单抗（Ofatumumab）的非治疗性生物类似药，与治疗性奥法木单抗共享相同的可变区序列，适配科研场景的精准应用需求。

奥法木单抗是一种全人源IgG1单克隆抗体，靶向CD20抗原——该抗原具有严格的细胞特异性：仅表达于前B细胞至成熟B细胞表面，但不表达于浆细胞（Plasma Cell），这一特性使其成为B细胞研究的关键工具。

产品通过结合CD20的膜近端表位，可诱导B细胞发生耗竭，核心作用机制包括：

• 补体依赖的细胞毒性（CDC）
• 抗体依赖的细胞介导的细胞毒性（ADCC）

适配研究领域覆盖：

• 慢性淋巴细胞白血病（CLL）的B细胞生物学机制研究
• B细胞介导的自身免疫性疾病（如类风湿关节炎等）的发病机制探索
• CD20抗原的表达调控规律与功能验证
• 癌症（如B细胞淋巴瘤）中B细胞耗竭的效应机制分析

科研应用场景

本产品经适用性验证，可用于以下科研实验：

• ELISA：定量检测样本中CD20抗原的表达水平
• FACS（流式细胞术）：分析人源B细胞群体的CD20表达特征与细胞亚群分布
• Functional Assay（功能实验）：评估抗体诱导B细胞耗竭的活性强度
• In Vivo研究：动物模型中探索B细胞耗竭对疾病进展的干预效应

储存与稳定性建议

为维持产品生物活性，需严格遵循以下储存条件，禁止反复冻融循环：

• 短期使用（1-2周内）：4°C避光保存
• 中期储存（最长12个月）：-20°C避光保存
• 长期储存（超过12个月）：-80°C避光保存

免疫原信息

本产品的免疫原具体详情，请参考随附的产品说明书。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human CD20 Antibody (Ofatumumab), Biosimilar, Research Use

Product Core Parameters

• English Name: BioSIM anti-Human CD20 Antibody (Ofatumumab Biosimilar), Research Grade
• Chinese Name: BioSIM Anti-Human CD20 Antibody (Ofatumumab), Biosimilar, Research Use
• CAS Number: 679818-59-8
• Supplier: InvivoCrown
• Catalog Number: SIM0067-5mg
• Size: 5mg
• Product Type: Secondary Antibody
• Host Species: Human (Fully Human)
• Reactivity: Human (Specifically recognizes human CD20 antigen)

Product Background and Scientific Characteristics

This product is a non-therapeutic biosimilar of Ofatumumab, sharing the same variable region sequence as the therapeutic Ofatumumab, designed to meet precise application requirements in research settings.

Ofatumumab is a fully human IgG1 monoclonal antibody that targets the CD20 antigen—an antigen with strict cell specificity: expressed only on the surface of pre-B cells to mature B cells, but not on plasma cells, making it a key tool for B cell research.

By binding to the membrane-proximal epitope of CD20, the product can induce B cell depletion, with core mechanisms including:

• Complement-Dependent Cytotoxicity (CDC)
• Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)

Suitable for research areas including:

• Studies on B cell biological mechanisms in Chronic Lymphocytic Leukemia (CLL)
• Exploration of pathogenesis in B cell-mediated autoimmune diseases (such as rheumatoid arthritis)
• Expression regulation patterns and functional validation of CD20 antigen
• Analysis of effector mechanisms of B cell depletion in cancers (such as B cell lymphoma)

Research Application Scenarios

This product has been validated for applicability in the following research experiments:

• ELISA: Quantitative detection of CD20 antigen expression levels in samples
• FACS (Flow Cytometry): Analysis of CD20 expression characteristics and cell subpopulation distribution in human B cell populations
• Functional Assay: Evaluation of the activity potency of antibody-induced B cell depletion
• In Vivo Studies: Exploration of the intervention effects of B cell depletion on disease progression in animal models

Storage and Stability Recommendations

To maintain the biological activity of the product, please strictly follow the storage conditions below. Repeated freeze-thaw cycles should be avoided:

• Short-term use (within 1-2 weeks): Store at 4°C protected from light
• Medium-term storage (up to 12 months): Store at -20°C protected from light
• Long-term storage (beyond 12 months): Store at -80°C protected from light

Immunogen Information

For specific details about the immunogen of this product, please refer to the accompanying product manual.

Note: The above information may be subject to change due to product optimization and upgrades. For specific information, please contact InvivoCrown.