BioSIM 抗人 CD20 抗体 (奥法木单抗 / 奥法妥

产品基本信息

• 英文名称：BioSIM anti-Human CD20 Antibody (Ofatumumab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 CD20 抗体 (奥法木单抗 / 奥法妥木单抗)，生物类似药，科研用途
• CAS号：679818-59-8
• 产品类型：二抗
• 供应商：InvivoCrown
• 产品货号：SIM0067-1mg
• 产品规格：1mg

产品概述

本产品为非治疗性生物类似药，与治疗性奥法木单抗共享相同可变区序列，专为科研场景设计，适配B细胞相关机制研究需求。

背景资料

奥法木单抗是全人源IgG1单克隆抗体，靶向CD20抗原——该抗原仅表达于前B细胞至成熟B细胞表面（浆细胞无表达）。通过结合CD20的膜近端表位，抗体可通过两种核心机制诱导B细胞耗竭：

• 补体依赖细胞毒性（CDC）：激活补体系统引发靶细胞裂解；
• 抗体依赖细胞介导的细胞毒性（ADCC）：招募效应细胞清除靶B细胞。

本产品适用于以下研究方向：

• B细胞介导的疾病机制解析；
• CD20生物学功能研究；
• 自身免疫性疾病中B细胞耗竭机制探索；
• 癌症研究（重点：慢性淋巴细胞白血病（CLL））。

关键属性

• 来源宿主：Human（全人源）
• 反应性：Human（仅识别人源CD20抗原）
• 免疫原：详见产品说明书

应用信息

本产品支持以下科研应用场景：

• ELISA：检测样本中CD20相关抗原或评估抗体结合活性；
• FACS：B细胞表型分析、分选或细胞亚群鉴定；
• Functional Assay：评估B细胞耗竭活性、CDC/ADCC效应功能；
• Research in vivo：动物模型中B细胞靶向耗竭的机制研究（注：本产品为科研用途，非治疗性）。

保存建议

为维持产品活性，需严格遵循以下储存条件，避免反复冻融：

• 短期需求（1-2周）：4°C避光保存；
• 中期储存（最长12个月）：-20°C避光保存；
• 长期储存：-80°C避光保存（可延长活性维持周期）。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Product Basic Information

• English Name: BioSIM anti-Human CD20 Antibody (Ofatumumab Biosimilar), Research Grade
• Chinese Name: BioSIM anti-Human CD20 Antibody (Ofatumumab), Biosimilar, Research Use
• CAS Number: 679818-59-8
• Product Type: Secondary Antibody
• Supplier: InvivoCrown
• Catalog Number: SIM0067-1mg
• Specification: 1mg

Product Overview

This product is a non-therapeutic biosimilar that shares the same variable region sequence with therapeutic Ofatumumab, specifically designed for research scenarios and suitable for B-cell related mechanism research.

Background Information

Ofatumumab is a fully human IgG1 monoclonal antibody that targets the CD20 antigen - an antigen expressed exclusively on the surface of pre-B cells to mature B cells (not expressed on plasma cells). By binding to the membrane-proximal epitope of CD20, the antibody can induce B cell depletion through two core mechanisms:

• Complement-Dependent Cytotoxicity (CDC): Activation of the complement system to induce target cell lysis;
• Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC): Recruitment of effector cells to eliminate target B cells.

This product is suitable for the following research directions:

• Analysis of B cell-mediated disease mechanisms;
• Study of CD20 biological functions;
• Exploration of B cell depletion mechanisms in autoimmune diseases;
• Cancer research (focus: Chronic Lymphocytic Leukemia (CLL)).

Key Attributes

• Source Host: Human (Fully human)
• Reactivity: Human (Recognizes only human CD20 antigen)
• Immunogen: Refer to product manual

Application Information

This product supports the following research application scenarios:

• ELISA: Detection of CD20-related antigens in samples or evaluation of antibody binding activity;
• FACS: B cell phenotypic analysis, sorting, or cell subset identification;
• Functional Assay: Evaluation of B cell depletion activity, CDC/ADCC effector functions;
• Research in vivo: Mechanistic studies of B cell-targeted depletion in animal models (Note: This product is for research use only, not therapeutic).

Storage Recommendations

To maintain product activity, strictly follow the storage conditions below, avoid repeated freeze-thaw cycles:

• Short-term (1-2 weeks): Store at 4°C protected from light;
• Medium-term storage (up to 12 months): Store at -20°C protected from light;
• Long-term storage: Store at -80°C protected from light (can extend activity maintenance period).

Note: The above information may change due to product optimization and upgrades. For specific information, please contact InvivoCrown.