BioSIM 抗人 FcRn 抗体 (罗扎诺利珠单抗)，生物

BioSIM 抗人 FcRn 抗体 (罗扎诺利珠单抗) - 生物类似药（科研用途）

英文名称：BioSIM anti-Human FcRn Antibody (Rozanolixizumab Biosimilar), Research Grade

产品基本信息

• 货号：SIM0054-5mg
• 规格：5mg
• 供应商：InvivoCrown
• 产品类型：重组生物类似二抗
• CAS号：1584645-37-3
• 来源宿主：人源化（Humanized）
• 反应性：仅识别人源（Human）抗原

产品背景与生产工艺

本产品为罗扎诺利珠单抗（Rozanolixizumab）的生物类似抗体，靶向人源FcRn（新生儿Fc受体），适用于科研领域相关机制研究。其生产过程遵循严格的杂质控制标准：

• 采用无动物成分的专用生产设施，全程避免动物源性蛋白、病毒等杂质引入；
• 使用体外无蛋白细胞培养技术，减少非目标蛋白对产品纯度的干扰；
• 经多步骤纯化组合工艺，包含Protein A/G亲和色谱核心步骤，确保抗体纯度与结合特异性。

关联研究领域：血小板减少症、重症肌无力（与FcRn介导的IgG代谢异常相关疾病）。

适用科研应用

本抗体支持多场景实验应用，具体如下：

• ELISA：用于定量检测抗原-抗体结合反应，可应用于FcRn蛋白表达水平分析；
• FACS（荧光激活细胞分选）：分析细胞表面FcRn的表达分布与相对含量；
• Functional Assay（功能实验）：评估抗体对FcRn介导的IgG转运/回收功能的调控；
• 体内研究（Research in vivo）：用于动物模型中探索FcRn靶点相关疾病的病理机制。

注：具体实验 protocol 请参考产品附带说明书。

储存与稳定性建议

为保障产品活性与稳定性，需严格遵循以下储存条件：

• 短期使用（1-2周）：4°C避光保存，避免反复冻融；
• 中期储存（最长12个月）：-20°C避光保存，建议分装为小体积（如100μg/管）以减少冻融次数；
• 长期储存（12个月以上）：-80°C避光保存，分装后可长期保持活性。

重要提示：反复冻融会导致抗体构象破坏，显著降低结合活性，需严格避免。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human FcRn Antibody (Rozanolixizumab) - Biosimilar (Research Use)

English Name:BioSIM anti-Human FcRn Antibody (Rozanolixizumab Biosimilar), Research Grade

Basic Product Information

• Catalog No.:SIM0054-5mg
• Size:5mg
• Supplier:InvivoCrown
• Product Type:Recombinant Biosimilar Secondary Antibody
• CAS No.:1584645-37-3
• Source Host:Humanized
• Reactivity:Reacts specifically with Human antigen

Product Background and Manufacturing Process

This product is a biosimilar antibody of Rozanolixizumab, targeting human FcRn (Neonatal Fc Receptor), suitable for mechanism research in scientific fields. Its manufacturing process follows strict impurity control standards:

• Utilizesanimal component-free dedicated production facilities to prevent introduction of animal-derived proteins, viruses, and other impurities throughout the process;
• Employsprotein-free in vitro cell culture technology to reduce interference from non-target proteins on product purity;
• Undergoesmulti-step purification combination process, including Protein A/G affinity chromatography as the core step, ensuring antibody purity and binding specificity.

Related research fields: Thrombocytopenia, Myasthenia Gravis (diseases associated with FcRn-mediated IgG metabolic abnormalities).

Applicable Research Applications

This antibody supports various experimental applications, as follows:

• ELISA: For quantitative detection of antigen-antibody binding reactions, applicable to FcRn protein expression level analysis;
• FACS (Fluorescence-Activated Cell Sorting): Analysis of expression distribution and relative content of FcRn on cell surface;
• Functional Assay: Evaluation of antibody regulation on FcRn-mediated IgG transport/recycling function;
• Research in vivo: Used for exploring pathological mechanisms of FcRn target-related diseases in animal models.

Note: For specific experimental protocols, please refer to the product instruction manual.

Storage and Stability Recommendations

To ensure product activity and stability, the following storage conditions must be strictly followed:

• Short-term use (1-2 weeks): Store at 4°C protected from light, avoid repeated freeze-thaw cycles;
• Medium-term storage (up to 12 months): Store at -20°C protected from light, recommended to aliquot into small volumes (e.g., 100μg/tube) to reduce freeze-thaw cycles;
• Long-term storage (more than 12 months): Store at -80°C protected from light, aliquoted product can maintain activity for extended periods.

Important Note: Repeated freeze-thaw cycles can cause antibody conformational damage and significantly reduce binding activity, which should be strictly avoided.

Note: The above information may be subject to change due to product optimization and upgrades. For specific information, please contact InvivoCrown.