BioSIM 抗人 PD-1/CD279 抗体 (信迪利 /

BioSIM 抗人 PD-1/CD279 抗体（信迪利单抗生物类似药，科研级）

英文名称：BioSIM anti-Human PD-1/CD279 Antibody (Sintilimab Biosimilar), Research Grade

产品货号：SIM0031-5mg

产品规格：5mg

产品类型：二抗（科研用途）

供应商：InvivoCrown

CAS号：2072873-06-2

关键特性

• 与信迪利单抗具有相同可变区，适配生物类似药相关基础研究
• 属于人源化IgG4κ单抗，携带S228P突变
• 对人PD-1（CD279）的亲和力高于纳武单抗/帕博利珠单抗
• 可与食蟹猴PD-1发生交叉反应，支持跨物种实验设计

背景与研究应用领域

PD-1（CD279）作为免疫检查点分子，通过与PD-L1结合调节免疫稳态；肿瘤细胞常利用该通路逃避免疫监视。

本产品为信迪利单抗的非治疗性生物类似药，适用于以下研究方向：

• 霍奇金淋巴瘤（HL）
• 非小细胞肺癌（NSCLC）
• 食管癌

适用实验类型

• ELISA：PD-1蛋白的定性/定量检测
• FACS：细胞表面PD-1表达水平分析
• Functional assay：PD-1通路阻断效果评估
• In vivo研究：动物模型（含食蟹猴）的肿瘤免疫实验

保存建议

• 严格避免反复冻融，以防抗体活性下降
• 短期储存（1-2周）：4°C避光保存
• 中期储存（最长12个月）：-20°C避光保存
• 长期储存：-80°C避光保存

免疫原信息

本产品免疫原细节请参考随附的产品说明书

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human PD-1/CD279 Antibody (Sintilimab Biosimilar), Research Grade

Product Name: BioSIM anti-Human PD-1/CD279 Antibody (Sintilimab Biosimilar), Research Grade

Catalog Number: SIM0031-5mg

Size: 5mg

Product Type: Secondary Antibody (For Research Use Only)

Supplier: InvivoCrown

CAS Number: 2072873-06-2

Key Features

• Shares identical variable regions with Sintilimab, suitable for basic research related to biosimilars
• A humanized IgG4κ monoclonal antibody with S228P mutation
• Affinity for human PD-1 (CD279) is higher than Nivolumab/Pembrolizumab
• Shows cross-reactivity with cynomolgus monkey PD-1, supporting cross-species experimental design

Background and Research Applications

PD-1 (CD279) as an immune checkpoint molecule regulates immune homeostasis by binding to PD-L1; tumor cells often utilize this pathway to evade immune surveillance.

This product is a non-therapeutic biosimilar of Sintilimab, suitable for the following research directions:

• Hodgkin's Lymphoma (HL)
• Non-Small Cell Lung Cancer (NSCLC)
• Esophageal Cancer

Suitable Experimental Types

• ELISA: Qualitative/quantitative detection of PD-1 protein
• FACS: Analysis of cell surface PD-1 expression levels
• Functional assay: Evaluation of PD-1 pathway blocking effects
• In vivo studies: Tumor immunity experiments in animal models (including cynomolgus monkeys)

Storage Recommendations

• Strictly avoid repeated freeze-thaw cycles to prevent decreased antibody activity
• Short-term storage (1-2 weeks): Store at 4°C protected from light
• Medium-term storage (up to 12 months): Store at -20°C protected from light
• Long-term storage: Store at -80°C protected from light

Immunogen Information

Please refer to the accompanying product manual for details of the immunogen for this product

Note: The above information may change due to product optimization and upgrades. Please consult InvivoCrown for specific information.