BioSIM 抗人 FcRn 抗体 (罗扎诺利珠单抗)，生物

BioSIM 抗人 FcRn 抗体 (罗扎诺利珠单抗生物类似药) - 科研级

一、产品核心信息

基础标识

• 英文全称：BioSIM anti-Human FcRn Antibody (Rozanolixizumab Biosimilar), Research Grade
• 中文全称：BioSIM 抗人 FcRn 抗体 (罗扎诺利珠单抗)，生物类似药，科研用途
• CAS号：1584645-37-3
• 供应商：InvivoCrown
• 产品货号：SIM0054-1mg
• 规格：1mg
• 产品类型：二抗

二、背景与生产工艺

本产品为罗扎诺利珠单抗的生物类似抗体，生产遵循严格的科研级标准：

• 在无动物成分的封闭设施中生产，避免动物源污染物交叉干扰；
• 采用体外无蛋白细胞培养技术，无需血清等动物源添加物；
• 经多步骤纯化工艺（含Protein A/G色谱），提升抗体纯度与结合特异性。

三、研究应用领域

聚焦自身免疫相关疾病的基础与转化研究，重点方向包括：

• 血小板减少症
• 重症肌无力

四、适用科研场景

适配多种实验类型，助力FcRn相关机制探索：

• ELISA：人源FcRn抗原定量检测或抗体结合活性分析；
• FACS：细胞表面FcRn表达的流式细胞术分析；
• Functional assay：FcRn功能活性的体外验证；
• Research in vivo：动物模型中FcRn相关生理/病理机制的体内研究。

五、来源与反应性

• 来源宿主：Humanized（人源化）—— 经人源化改造，降低人体相关实验的免疫原性风险；
• 反应性：Human（人源）—— 特异性结合人源FcRn分子。

六、储存与稳定性建议

为维持抗体活性，需遵循以下条件：

• 严格避免反复冻融（建议分装为小体积，减少冻融次数）；
• 短期使用（1-2周）：4°C避光保存；
• 中期储存（最长12个月）：-20°C避光保存；
• 长期储存：-80°C避光保存（分装后可延长活性保持时间）。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human FcRn Antibody (Rozanolixizumab Biosimilar) - Research Grade

II. Product Core Information

Basic Identification

• Full English Name: BioSIM anti-Human FcRn Antibody (Rozanolixizumab Biosimilar), Research Grade
• Full Chinese Name: BioSIM 抗人 FcRn 抗体 (罗扎诺利珠单抗)，生物类似药，科研用途
• CAS Number: 1584645-37-3
• Supplier: InvivoCrown
• Product Number: SIM0054-1mg
• Specification: 1mg
• Product Type: Secondary Antibody

II. Background and Production Process

This product is a biosimilar antibody of rozanolixizumab, produced following strict research-grade standards:

• Produced in animal component-free closed facilities to avoid cross-contamination from animal-derived pollutants;
• Utilizes in vitro protein-free cell culture technology, eliminating the need for animal-derived additives such as serum;
• Purified through a multi-step purification process (including Protein A/G chromatography) to enhance antibody purity and binding specificity.

III. Research Application Areas

Focused on basic and translational research of autoimmune-related diseases, with key directions including:

• Thrombocytopenia
• Myasthenia Gravis

IV. Applicable Research Scenarios

Compatible with various experimental types to facilitate FcRn-related mechanism exploration:

• ELISA: Quantitative detection of human FcRn antigen or analysis of antibody binding activity;
• FACS: Flow cytometry analysis of FcRn expression on cell surfaces;
• Functional assay: In vitro verification of FcRn functional activity;
• Research in vivo: In vivo study of FcRn-related physiological/pathological mechanisms in animal models.

V. Source and Reactivity

• Source Host: Humanized - Engineered through humanization to reduce immunogenicity risks in human-related experiments;
• Reactivity: Human - Specifically binds to human FcRn molecules.

VI. Storage and Stability Recommendations

To maintain antibody activity, the following conditions should be followed:

• Strictly avoid repeated freeze-thaw cycles (recommend aliquoting into small volumes to reduce freeze-thaw times);
• Short-term use (1-2 weeks): Store at 4°C protected from light;
• Medium-term storage (up to 12 months): Store at -20°C protected from light;
• Long-term storage: Store at -80°C protected from light (aliquoting can extend the duration of activity retention).

Note: The above information may be subject to change due to product optimization and upgrades. For specific information, please consult InvivoCrown.