BioSIM 抗人 HGF/SF 抗体 (非拉妥组单抗)，生

BioSIM 抗人 HGF/SF 抗体 (非拉妥组单抗)，生物类似药，科研用途

英文名称：BioSIM anti-Human HGF/SF Antibody (Ficlatuzumab Biosimilar), Research Grade | CAS号：1174900-84-5

产品核心信息

• 供应商：InvivoCrown
• 产品货号：SIM0140-1mg
• 产品规格：1mg
• 产品类型：二抗

背景与生产工艺

该抗体为非拉妥组单抗的生物类似药，仅用于科研场景。生产环节遵循严格的生物制品制备标准：

• 生产环境：无动物成分的专用设施，降低外源性动物源污染物引入风险
• 培养技术：体外无蛋白细胞培养技术，减少杂蛋白对抗体纯度的干扰
• 纯化工艺：多步骤纯化流程，包含Protein A或G色谱工艺，可提升抗体纯度及生物活性的稳定性

研究领域

聚焦头颈部鳞状细胞癌（SCCHN）研究——HGF/SF信号通路在该癌种的增殖、侵袭等生物学过程中具有关键作用，此抗体可作为工具用于相关机制的探索分析。

应用类型与适用场景

• ELISA：人源HGF/SF的定量检测，辅助样本中目标蛋白含量的分析
• FACS：细胞表面HGF/SF表达水平的流式分析，用于细胞表型的鉴定
• Functional assay：评估抗体对HGF/SF生物学功能（如信号传导、细胞增殖等）的影响
• Research in vivo：动物模型中开展人源HGF/SF相关的体内实验研究

免疫原与来源宿主

• 来源宿主：Humanized（人源化），可降低体内实验中的免疫排斥反应风险
• 免疫原信息：详细内容请参考产品配套说明书

反应性

仅针对人源（Human）HGF/SF具有特异性反应，适用于人源样本的相关研究。

保存建议

为维持抗体活性与稳定性，需遵循以下储存规范：

• 避免反复冻融（RFT），以防抗体空间结构破坏
• 短期需求（1-2周）：4°C避光保存
• 中期储存（最长12个月）：-20°C避光保存
• 长期储存：-80°C避光保存，建议分装后储存以减少冻融次数

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM anti-Human HGF/SF Antibody (Ficlatuzumab Biosimilar), Research Use Only

English Name: BioSIM anti-Human HGF/SF Antibody (Ficlatuzumab Biosimilar), Research Grade | CAS Number: 1174900-84-5

Product Core Information

• Supplier: InvivoCrown
• Catalog Number: SIM0140-1mg
• Size: 1mg
• Product Type: Secondary Antibody

Background and Production Process

This antibody is a biosimilar of Ficlatuzumab, intended for research use only. The production process follows strict standards for biological product manufacturing:

• Production Environment: Animal-free dedicated facilities to reduce the risk of introducing exogenous animal-derived contaminants
• Culture Technology: In vitro protein-free cell culture technology to minimize interference from impure proteins on antibody purity
• Purification Process: Multi-step purification process including Protein A or G chromatography to enhance antibody purity and stability of biological activity

Research Field

Focusing on Squamous Cell Carcinoma of the Head and Neck (SCCHN) research—the HGF/SF signaling pathway plays a key role in biological processes such as proliferation and invasion in this cancer type. This antibody can be used as a tool for exploring and analyzing related mechanisms.

Application Types and Suitable Scenarios

• ELISA: Quantitative detection of human HGF/SF, assisting in the analysis of target protein content in samples
• FACS: Flow cytometry analysis of HGF/SF expression levels on cell surface, used for cell phenotype identification
• Functional assay: Evaluation of the antibody's effects on HGF/SF biological functions (such as signal transduction, cell proliferation, etc.)
• Research in vivo: Conducting in vivo experimental studies related to human HGF/SF in animal models

Immunogen and Host Source

• Host Source: Humanized, reducing the risk of immune rejection in in vivo experiments
• Immunogen Information: Please refer to the product manual for detailed information

Reactivity

Specifically reacts only with Human HGF/SF, suitable for research on human samples.

Storage Recommendations

To maintain antibody activity and stability, the following storage guidelines should be followed:

• Avoid repeated freeze-thaw cycles (RFT) to prevent damage to the antibody's spatial structure
• Short-term storage (1-2 weeks): Store at 4°C protected from light
• Medium-term storage (up to 12 months): Store at -20°C protected from light
• Long-term storage: Store at -80°C protected from light, aliquoting is recommended to reduce freeze-thaw cycles

Note: The above information may be subject to change due to product optimization and upgrades. For specific information, please contact the company.