- ￥99 - 999
- Sigma
- 进口
- C7495-25MG
- 2026年04月27日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
RT
- 保质期：
见标签
- 库存：
999
- 供应商：
鹿森生物
- 规格：
25MG
Application
Clofarabine has been used in a cell viability assay to analyze the sensitivity of the isogenic cell lines towards clofarabine. It is also used to study the interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein.
Biochem/physiol Actions
Clofarabine is a second-generation nucleoside analog, used in cancer treatments. Clofarabine is metabolized to 5′-triphosphate and is known to block DNA synthesis. The human equilibrative nucleoside transporters (hENT1 and hENT2) and human concentrative nucleoside transporter (hCNT2 and hCNT3) mediates clofarabine transport into the cell. It also serves as a substrate for mitochondrial deoxyguanosine kinase. Clofarabine is an inhibitor of ribonucleotide reductase. It resists the phosphorolytic cleavage catalyzed by purine nucleoside phosphorylase of bacterias. Clofarabine also withstands deamination by adenosine deaminase.
Clofarabine is a purine nucleoside antimetabolite. Clofarabine is toxic to nondividing lymphocytes and monocytes.
Clofarabine is an antimetabolite toxic to nondividing lymphocytes and monocytes.
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文献和实验（1～2meq/kg）；先麻醉，之后断头；先麻醉，之后颈椎脱臼；B动物清醒中直接断头；动物清醒中直接颈椎脱臼；乙醚；C电击。2、125g～1kg啮齿动物、兔A二氧化碳；Barbiturate注射液，静脉注射（100mg/kg）；Barbiturate注射液，腹腔注射（100mg/kg）；先麻醉，之后采血致死；先麻醉，之后静脉注射KCl（1～2meq/kg）；先麻醉，之后断头；先麻醉，之后颈椎脱臼；B动物清醒中直接断头；C动物清醒中直接颈椎脱臼；乙醚；电击。3、1kg～5kg啮齿动物、兔A二氧
包装 1mg或更少的多肽按净重包装，声明的小瓶重不含相关抗离子和水。 例如，氨基酸分析决定的肽含量是80%， 在1mg样品中，那么瓶中毛重是1.25mg。 大量的多肽以毛重算。标出的重量含相关抗离子和水， 例如，25mg样品中肽百分比为90%，那么，实际肽量为25mg×90%=22.5mg 不要把肽含量和纯度搞混了。肽的纯度可能是100%， 而肽含量相关带电基团（如Arg, Lys ）的抗离子量和肽新水性决定。这是合成肽的本身特性。 冻干肽的保存 所有产品应
用DAPI进行细胞染色DAPI的配置Stock solution of 1mg/ml in ddH2O; working solution of 0.25mg/ml to 50mg/ml in ddH2O or PGM.1.Place sample on slide.2.Add a few drops working solution.3.Squash and view.Staining � DAPI Staining for Cells:Separately DAPI staining
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