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PD-1 Mouse mAb(bsm-41117M)-50u

l/100ul/200ul
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  • ￥1180 - 2800
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  • bsm-41117M
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号 bsm-41117M
    英文名称 PD-1 Mouse mAb
    中文名称 程序性死亡1（CD279）单克隆抗体
    英文别名 Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD-1; hSLE1; PD 1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2.
    产品应用 IHC-P=1:50-200, IHC-F=1:50-200, IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.
    交叉反应 Human
    抗体来源 Mouse
    免疫原 Recombinant human PD1
    亚型 IgG1
    性状 Liquid
    纯化方法 affinity purified by Protein G
    克隆类型 Monoclonal
    理论分子量 32 kDa
    浓度 1mg/1ml
    储存液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis

    Cancer > Invasion/microenvironment > Apoptosis

    Cancer > Tumor immunology > CD markers

    Cell Biology > Apoptosis > Receptors > Death Receptors

    Immunology > Adaptive Immunity > Regulatory T Cells

    Immunology > Adaptive Immunity > T Cells > CD
    亚基 Monomer.
    亚细胞定位 Membrane; Single-pass type I membrane protein.
    组织特异性

    Expressed in lymph node and 85 other tissues
    相似性 Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    功能

    Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005).
    Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005).
    Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
    Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).

    The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311).

    The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311).
    The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).
    保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料 Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]

     

    应用 推荐稀释比例
    {IHC-P} {1:50-200}
    {IHC-F} {1:50-200}
    {IF} {1:50-200}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded Human Tonsil; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with PD-1 Monoclonal Antibody, Unconjugated(bsm-41117M) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
    产品细节图片2
    P‌‌araformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with PD-1 Monoclonal Antibody, Unconjugated(bsm-41117M) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 6.3 }}] {Qiao-xin Lin. et al.Sequential treatment of anti-PD-L1 therapy prior to anti-VEGFR2 therapy contributes to more significant clinical benefits in non-small cell lung cancer.neoplasia.2025 Jan:59:101077.} {IHC} {Mouse}

    [IF={{ 5.6 }}] {Meiying Song. et al. Pathogenic Th17 cell-mediated liver fibrosis contributes to resistance to PD-L1 antibody immunotherapy in hepatocellular carcinoma. INT IMMUNOPHARMACOL. 2024 Mar;129:111601} {IHC} {Mouse}

    [IF={{ 2.5 }}] {Wang Qi. et al. Correlation between PD-1/PD-L1 and RANKL/OPG in chronic apical periodontitis model of Sprague-Dawley rats. ODONTOLOGY. 2024 Mar;:1-10} {IHC} {Rat}

    相关实验

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    • WHOLE MOUNT IN SITU HYBRIDIZATION. Mouse Embryos

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    • Hybrid Resistance by Mouse NK Cells In Vitro

      A purified NK cells to kill H2d target cells can be reversed by adding MAb reagents that bind to either Ly49A or H2-Dd . We and others have extended these early findings to the Ly49C and I subsets of NK cells, and have recently detected positive signaling

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    文献支持
    PD-1 Mouse mAb(bsm-41117M)-50ul/100ul/200ul
    ￥1180 - 2800