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- bs-10219P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-10219P |
| 英文名称 | Agrin Antibody Blocking Peptide |
| 中文名称 | 聚集蛋白封闭多肽 |
| 英文别名 | AGRIN; Agrin proteoglycan; AGRN; FLJ45064; OTTHUMP00000044043; AGRIN_HUMAN; AGRIN_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Cell Type Marker > Neuron marker > Growth Cone Neuroscience > Neurology process > Neural Signal Transduction |
| 亚基 | Interacts with LRP4; the interaction is direct and recruits AGRIN to the MUSK signaling complex composed at least of MUSK and LRP4 (By similarity). Binds to laminin. |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix. Note=Synaptic basal lamina at the neuromuscular junction. |
| 组织特异性 | Detected on the aortic endothelium (at protein level). |
| 翻译后修饰 | Contains heparan sulfate chains as well as N-linked and O-linked oligosaccharides. 0-fucosylation of EGF repeat 4 of muscle AGRN by POFUT1 prevents its ability to form AChR clusters. |
| 相似性 | Contains 4 EGF-like domains. Contains 9 Kazal-like domains. Contains 2 laminin EGF-like domains. Contains 3 laminin G-like domains. Contains 1 NtA (N-terminal agrin) domain. Contains 1 SEA domain. |
| 功能 | Plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Ligand of the MUSK signaling complex that directly binds LRP4 in this complex and induces the phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. [provided by RefSeq, Aug 2011]. |
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Agrin Antibody Blocking Peptide(bs-10219P)-500ug
￥880
