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- 2025年10月16日
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500ug
| 产品编号 | bs-1849P |
| 英文名称 | MDK Antibody Blocking Peptide |
| 中文名称 | 中期因子/肝素结合生长因子封闭多肽 |
| 英文别名 | Amphiregulin associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; MK 1; MK; MK1; NEGF 2; NEGF2; neurite growth promoting factor 2; Neurite outgrowth promoting protein; MK_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Neurotrophins Neuroscience > Neurology process > Neurogenesis |
| 亚基 | Homodimer. Interacts with ALK. |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the pleiotrophin family. |
| 功能 | Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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