- ￥880
- Bioss
- bs-9773P
- 2025年10月16日
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500ug
| 产品编号 | bs-9773P |
| 英文名称 | ENKUR Antibody Blocking Peptide |
| 中文名称 | 10号染色体开放阅读框63封闭多肽 |
| 英文别名 | DKFZp781F21103; Chromosome 10 open reading frame 63; ENKUR; Enkurin; ENKUR_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Signaling Pathway > Calcium Signaling Signal Transduction > Signaling Pathway > Calcium Signaling > Calmodulin Pathway |
| 亚基 | Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity). |
| 亚细胞定位 | Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and flagellar principal piece. |
| 相似性 | Contains 1 IQ domain. |
| 功能 | Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Enkurin is a 256 amino acid adapter protein that brings signal transduction proteins and transient receptor potential canonical (TRPC) cation channels into contact. Localizing to the acrosomal crescent and flagellar principal piece of sperm, Enkurin contains one IQ domain which it uses to bind CaM (calmodulin). Enkurin is highly expressed in testis and vomeronasal organ, but is also found at lower levels in brain, ovary, heart and lung. The gene encoding Enkurin maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10. |
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ENKUR Antibody Blocking Peptide(bs-9773P)-500ug
￥880
